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. 2013 Mar 28;8(3):e60394. doi: 10.1371/journal.pone.0060394

Figure 1. Treatment of SLE afflicted (NZBxNZW)F1 mice with hCDR1 results in the down regulation of IFN-α.

Figure 1

(A) Mean percentage (±SE) results of 4 independent experiments in which the mRNA expression of IFN-α was determined in pools of spleen derived cells of SLE afflicted mice (10–12 mice per group) treated with vehicle, hCDR1, or the control, scrambled, peptide. The levels of gene expression were determined by real-time RT-PCR and calculated relatively to levels in cells from vehicle-treated mice (considered as 100%). (B) Mean concentrations (±SE) of IFN-α determined by ELISA in sera of the same groups of mice.