Table 3.

Average bioavailabilities and half-lives of progestogens

Progestogen	Dose (mg)	Bioavailability (%)	Half-life (h)	Ref.
Progesterone	100, 200, 300	<5	16.2–18.3	16
MPA	10	>90	24	17
Megestrol acetate	160	NA	22.3	18
Cyproterone acetate	2	NA	54.0–78.6	19
Chlormadinone acetate	2	∼100	80.1	20
Medrogestone	5	NA	34.9	21
Dydrogesterone	10	28	14–17	—a
Nomegestrol acetate	2.5	60	50	22
Trimegestone	0.5	∼100	15	—a
Norethindrone	1	64	8	23
Levonorgestrel	0.15–0.25	89/99b	9.9/13.2b	24
Desogestrel	0.15	62/76b	11.9/23.8b	25, 26
Gestodene	0.075	87/99b	12–14	27, 28
Dienogest	4	96.2	10.8/11.6b	29
Drospirenone	3	66	31.1–32.5	30, 31

NA, No data available.

^aThe data were obtained from a package insert.

^bMultiple bioavailability or half-life values are shown.