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. 2013 Mar 28;8(3):e57606. doi: 10.1371/journal.pone.0057606

Figure 4. Kinetics of anti-Aß Ab production by mice injected with Aß mAb-expressing AAV.

Figure 4

Normal C57BL/6 mice (n = 10/group) received a single intramuscular injection with 3.0×109, 3.0×1010, 3.0×1011 vg of Aß mAb-expressing AAV or 3.0×1011 vg of LacZ-expressing AAV vector. The titer of IgG1 Ab binding to Aß1–42 was detected at indicated time points. Significant difference among groups received 3×109, 3×1012 and 3×1011 vg of Aß mAb-expressing AAV was observed from 2-week to 64-week after administration (P<0.05). Data are presented as mean ± SE.