Figure 6. Therapy of AD using Aß mAb-expressing AAV vector.

Tem-month old Tg2576 mice were injected i.m. with 3.0×10¹⁰ vg of the Aß mAb - expressing AAV vector. (A) Scheme of experiment. (B) The amount of Aß protein in brain extracts was determined using anti-Aß Ab-coated ELISA plates at age 10-, 13-, 15- and 17-month old (4–5 mice per time point). C57BL/6 mice were used as controls. Data are presented as mean ± SE. (C) Brain sections from Tg2576 or C57BL/6 mice were examined for Aß deposits by immunohistostaining using rabbit anti-human beta amyloid 1–42 polyclonal antibody.