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. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Chem Res Toxicol. 2012 Nov 6;26(1):55–66. doi: 10.1021/tx300366k

Figure 3.

Figure 3

Production of the various GSH conjugates of capsaicin by individual recombinant P450 enzymes. Reactions were performed as outlined in the methods section with a concentration of 25 µM capsaicin. Data using a 100 µM concentration and additional P450 enzymes are presented as Supplemental Figure 10. The identities of the conjugates and the specific MS2 analysis parameters used for metabolite detection are provided in the figures above the corresponding results from the enzyme screen. All data are relative to the amount of conjugate observed using human liver microsomes (n=3). *Represents a statistical difference in the amount of conjugate produced by a specific P450 enzyme relative to human liver microsomes using ANOVA and p<0.05.