Table 2.
MDM2 and p14ARF genotype frequencies and risk estimates for DTC and PTC
| Genotypes | Controls (No. = 511) | DTC cases (No. = 303) | P* | PTC cases (No. = 273) | P* | Adjusted OR† (95% CI) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
||||||||
| No. | (%) | No. | (%) | No. | (%) | DTC | PTC | |||
| MDM2 rs2279744 | ||||||||||
| TG/GG | 341 | (66.7) | 173 | (57.1) | 118 | (43.2) | 1.0 | 1.0 | ||
| TT | 170 | (33.3) | 130 | (42.9) | 0.006 | 155 | (56.8) | 0.006 | 1.5 (1.1–2.0) | 1.5 (1.1–2.1) |
| MDM2 rs937283 | ||||||||||
| AA | 173 | (33.9) | 104 | (34.3) | 92 | (33.7) | 1.0 | 1.0 | ||
| AG/GG | 338 | (66.1) | 199 | (65.7) | 0.892 | 181 | (66.3) | 0.965 | 1.0 (0.7–1.3) | 1.0 (0.7–1.4) |
| p14ARF rs3731217 | ||||||||||
| TT | 388 | (75.9) | 198 | (65.4) | 181 | (66.3) | 1.0 | 1.0 | ||
| TG/GG | 123 | (24.1) | 105 | (34.6) | 0.001 | 92 | (33.7) | 0.004 | 1.7 (1.2–2.3) | 1.5 (1.1–2.2) |
| p14ARF rs3088440 | ||||||||||
| GG | 402 | (78.7) | 241 | (79.5) | 216 | (79.1) | 1.0 | 1.0 | ||
| GA/AA | 109 | (21.3) | 62 | (20.5) | 0.769 | 57 | (20.9) | 0.883 | 1.1 (0.7–1.5) | 1.1 (0.7–1.6) |
*
Chi-square test, compared to controls.
†
Adjusted for age, sex, race/ethnicity, first degree family history of cancer, smoking status, alcohol drinking status, and radiation exposure.
Abbreviations: MDM2, murine double minute 2; DTC, differentiated thyroid carcinoma; OR, odds ratio; PTC, papillary thyroid carcinoma.