Serum IGF-1 Levels for Ad libitum-Fed (AL), Chronic Calorie Restricted (CCR) and Intermittent Restricted (ICR) TGF-α Mice (combined with and without mammary tumor) over the Course of the Study. Bars represent means of IGF-1 concentrations. Cycle 5: ANOVA P<0.001. AL n = 36, CCR n= 36, ICR-Refed n=18 and ICR-Restricted n=18. Cycle 8: ANOVA P<0.05. AL n = 36, CCR n= 36, ICR-Refed n=18 and ICR-Restricted n=18. Cycle 11: ANOVA P<0.001. AL n = 32, CCR n= 36, ICR-Refed n=18 and ICR-Restricted n=18.