Table 1.
Lesion-based sensitivity of 18F-FDOPA PET across different tumour locations in relation to genotype.
| A Parasympathetic (HNPGL and parasympathetic thoracic) | B Adrenal | C Sympathetic Extra-adrenal (Abdominal and sympathetic thoracic) | All locations | |
|---|---|---|---|---|
| Number of PGL/PHEO | 109 [57/52] | 49 [16/33] | 37 [17/20] | 195 [90/105] |
| Per-lesion sensitivity | 107 (98.2%) [96.5%/100%] | 46 (93.9%) [93.8%/93.9%] | 26 (70.3%) [47.1%/90%] | 179 (91.8%) [86.7%/96.2%] |
| Genotype of 18F-FDOPA negative tumours | 1 SDHD, 1 sporadic | 3 SDHD | 7 SDHD 4 SDHB |
1 sporadic [1/0] 11 SDHD [8/3] 4 SDHB [3/1] |
Results of the two series are detailed ([Timone/NIH]) just below the pooled results.
*
The SDHD-related vagal PGL was millimetric and located just below another highly avid PGL of the vagus nerve.
**
The sporadic carotid body tumour was mainly fibrotic, with a minimal residual volume of neuroendocrine tissue.
18F-FDOPA PET was more sensitive in parasympathetic PGL than in sympathetic PGL. A vs B vs C: P<0.001, A vs B: P=0.173, A vs C: P<0.001, B vs C: P=0.006, A vs B+C: P<0.001 (Fisher’s exact test).