Table 2.

Clusters showing positive correlations between ApEn and MMSE, and negative correlations between ApEn and CDR

Brain Region	Cluster Centraid (x, y, z)	Cluster Size (kc)	Peak T	Peak SVC p
MMSE Positive Correlation
Left Postcentral Gyrus	−24,−32, 68	49	6.52	0.001
Right Precuneus	8, −70, 56	103	6.22	0.002
Right Supramarginal Gyrus	56,−42,30	52	5.85	0.002
Right Paracentral Lobule	8, −38, 72	38	5.50	0.002
Right Angular Gyrus	44, −62, 40	19	4.85	0.009
Right Mid Temporal Gyrus	46, 0, −20	27	4.44	0.044
Right Putamen	30, 6, 2	12	4.41	0.013
Left Lingual Gyrus	−14, −68, −12	19	4.36	0.027
Left Precuneus	−14, −64, 60	10	3.92	0.084⊗
CDR-SOB Negative Correlation
Right Supramarginal Gyrus	56, −44, 28	57	6.61	0.001
Right Precuneus	6, −72, 54	164	6.08	0.002
Right Paracentral Lobule	8, −38, 74	28	5.27	0.002
Left Postcentral Gyrus	−22, −32, 70	33	5.11	0.008
Right Angular Gyrus	44, −64, 38	11	4.20	0.029

Age and mutation status are included in the regression analyses. Level of significance is set at uncorrected p=0.001 (T=3.9), with k_c ≥ 10. Peak p values after small volume correction using AAL ROIs are shown. All except the left precuneus cluster (^⊗) have peak SVC p<0.05