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Domain structures of collagenolytic proteases. A, MMP-1, MMP-8, and MMP-13. B, MT1-MMP. C, MMP-2 and MMP-9. D, cathepsin K. E, neutrophil elastase. F, fiddler crab collagenase. G, C. histolyticum class I collagenase (ColG). Signal, secretory signaling peptide; Pro, prodomain; TM, transmembrane domain; CT, cytoplasmic tail; FN, fibronectin domain; Pre, predomain; PKD, polycystic kidney disease-like domain.
