TABLE 1.
Representative protease cleavage sites within interstitial collagen triple-helical domains
| Enzyme | Collagen chain | Sequencea |
|---|---|---|
| MMP-1/2/8/9/12/13 and MT1-MMP | α1(I) | Pro-Gln-Gly775∼Ile776-Ala-Gly |
| MMP-1/2/8/9/12/13 and MT1-MMP | α2(I) | Pro-Gln-Gly775∼Leu776-Leu-Gly |
| MMP-1/8/13 and MT1-MMP | α1(II) | Pro-Gln-Gly775∼Leu776-Ala-Gly |
| MMP-1/8/9/12/13, MT1-MMP, and MT3-MMP | α1(III) | Pro-Leu-Gly775∼Ile776-Ala-Gly |
| Cathepsin K | α1(I) | Gly-Pro-Arg9∼Gly10-Leu-Pro |
| Cathepsin K | α1(I) | Gly-Pro-Gln21∼Gly22-Phe-Gln |
| Cathepsin K | α1(I) | Gly-Leu-Asp96∼Gly97-Ala-Lys |
| Cathepsin K | α1(I) | Gly-Pro-Gln189∼Gly190-Val-Arg |
| Cathepsin K | α1(I) | Gly-Pro-Ser810∼Gly811-Ala-Ser |
| Cathepsin K | α2(I) | Gly-Pro-Arg9∼Gly10-Pro-Pro |
| Cathepsin K | α2(I) | Gly-Pro-Gln21∼Gly22-Phe-Gln |
| Cathepsin K | α2(I) | Gly-Leu-Lys99∼Gly100-Pro-Gln |
| Cathepsin K | α2(I) | Gly-Ala-Arg144∼Gly145-Ser-Asp |
| Cathepsin K | α2(I) | Pro-Pro-Gly814∼Ala815-Arg-Gly |
| Cathepsin K | α1(II) | Lys-Pro-Gly61∼Lys62-Ser-Gly |
| Elastase | α1(III) | Ala-Gly-Ile779∼Thr780-Gly-Arg |
| Crab collagenase 1 | α1(I) | Ala-Gly-Gln779∼Arg780-Gly-Val |
| Crab collagenase 1 | α1(I) | Gly-Gln-Arg780∼Gly781-Val-Val |
| Crab collagenase 1 | α1(I) | Gly-Glu-Arg792∼Gly793-Phe-Hyp |
| Crab collagenase 1 | α1(I) | Arg-Gly-Leu587∼Thr588-Gly-Pro |
| Crab collagenase 1 | α2(I) | Gly-Phe-Leu783∼Gly784-Leu-Pro |
| Cardosin A | α2(I) | Pro-Gly-Phe464∼Asn465-Gly-Leu |
| Kumamolisin-As/ScpA | α1(I) | Gly-Pro-Lys108∼Gly109-Glu-Hyp |
| Kumamolisin-As/ScpA | α1(I) | Gly-Pro-Arg183∼Gly184-Ser-Glu |
| Kumamolisin-As/ScpA | α1(I) | Gly-Ala-Arg396∼Gly397-Gln-Ala |
| Kumamolisin-As/ScpA | α1(I) | Gly-Asp-Ala489∼Gly490-Ala-Hyp |
| Kumamolisin-As/ScpA | α2(I) | Gly-Pro-Arg42∼Gly43-Pro-Ala |
| GP2 | α1(I) | Gly-Pro-Ala285∼Gly286-Glu-Glu |
| GP2 | α1(I) | Gly-Ala-Arg498∼Gly499-Glu-Arg |
| GP2 | α1(I) | Gly-Pro-Ser711∼Gly712-Asn-Ala |
| GP2 | α2(I) | Gly-Pro-Ser285∼Gly286-Glu-Glu |
| GP2 | α2(I) | Gly-Ala-Arg498∼Gly499-Glu-Arg |
| GP2 | α2(I) | Gly-Pro-Ser711∼Gly712-Ile-Ser |
| ColG | α1(II) | Gly-Phe-Gln24∼Gly25-Asn-Pro |
| ColG | α1(III) | Gly-Glu-Arg69∼Gly70-Leu-Hyp |
| ColH | α1(I) | Gly-Ala-Arg396∼Gly397-Gln-Ala |
| ColH | α2(I) | Gly-Ala-Arg396∼Gly397-Glu-Pro |
| ColH | α1(II) | Gly-Phe-Pro405∼Gly406-Pro-Lys |
| ColH | α1(III) | Gly-Pro-Arg399∼Gly400-Gln-Hyp |
a Numbering begins at the N terminus of the triple-helical region of each collagen.