FIGURE 8.

Tentative model of the assembly of the core retromer to endosomal membranes in plants. The core retromer assembles first in the cytosol (1) and then is recruited to the endosomal membrane through an interaction between VPS35 and RABG3f (2). This recruitment occurs independently of SNX proteins. SNXs participate in certain functions of the core retromer through the formation of membrane-bound heterodimers consisting of SNX1 and SNX2s. In plants, SNX1 is the only SNX capable of binding to the membrane of endosomes (3) and will recruit cytosolic SNX2s to form a functional SNX complex (4).