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. 2013 Feb 5;288(13):9001–9010. doi: 10.1074/jbc.M112.437897

FIGURE 7.

FIGURE 7.

TCF12 is involved in rHSP90α-induced CRC cell migration and invasion. Cell migration tracks were monitored and analyzed for representative control (ctrl) and TCF12-knockdown LoVo (A) and SW620 (B) cells during incubation with PBS or 15 μg/ml rHSP90α for 16 h. Twenty cells in each treatment group were randomly selected, and their accumulated and oriented migration distances were quantified and expressed as means ± S.D. The representative results of three independent experiments indicate that rHSP90α-induced CRC cell migration could be significantly prevented by knockdown of cellular TCF12 expression. *, p < 0.05. Additionally, cell invasiveness was investigated by the Transwell invasion assay for control and TCF12-knockdown LoVo (C) and SW620 (D) cells that had been treated for 24 h with PBS or 15 μg/ml rHSP90α. The means ± S.D. of three independent experiments show that rHSP90α-induced CRC cell invasion could be significantly prevented by knockdown of cellular TCF12 expression.