FIGURE 1.

ODCase catalyzing reaction and its reaction center. A, substrates and products of decarboxylation and cyano-converting reactions. B, reaction center of MtODCase in complex with 6-hydroxy-UMP (BMP, Protein Data Bank (PDB): 1lor (29)). Transparent spheres indicate the van der Waals radii of the four charged side chains Lys-42, Asp 70, Lys-72, and Asp-75′ (′ indicates that the residue belongs to the second subunit of the dimeric enzyme). Numbers beside the dotted lines represent the distances between the connected atoms in Angstroms.