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. 2013 Feb 19;288(13):9261–9271. doi: 10.1074/jbc.M112.433730

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — KLF4 down-regulated the expression of miR-143. A, qRT-PCR shows overexpression of KLF4 can down-regulate the expression of miR-143. C, predicted potential binding sites of KLF4 in the 3 kb upstream region of miR-143. B, ChIP analysis of KLF4 binding sites in the 3 kb within the upstream of miR-143. C, Dual-Luciferase assay showing different luciferase (Luc) activity of the mutated promoter of miR-143. Luciferase activities were normalized with the relative activity of pGL-WT-Luc co-transfected with KLF4. Asterisks indicate statistical significance compared with the negative control groups. *, p < 0.05; **, p < 0.01. D, schematic diagram showing the regulatory relationships among miR-143, miR-145, Klf4 and Osx during odontoblast differentiation.