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. 2013 Feb 12;288(13):9293–9302. doi: 10.1074/jbc.M113.455816

FIGURE 5.

FIGURE 5.

Potentiation of EP2 receptors in classically activated microglia. A and B, EP2 potentiator TG3-95-1 at 20 μm was used to determine how EP2 potentiation affected cAMP levels induced by PGE2 and butaprost in rat primary microglia. C, effect of EP2 potentiator on the COX-2 mRNA expression in the presence of 100 nm butaprost in classically activated microglia. Data are expressed as mean ± S.E. (error bars), n = 4. Changes in COX-2, iNOS, and IL-6 mRNA expression (D) and TNF-α, CCL3, and CCL4 mRNA expression (E) caused by 20 μm EP2 potentiator TG3-95-1 in the presence of 100 nm butaprost in classically activated microglia. *, p < 0.05; **, p < 0.01; ***, p < 0.001. L/I, LPS/IFN-γ.