FIGURE 8.

Expression of Mt-NPM1 and higher expression of MEF/ELF4 are associated with the elevated expression of HDM2 in CD34-positive AML cells. Total RNA isolated from 22 AML patients (CD34-positive leukemia cells) was analyzed for the expression of HDM2 by RQ-PCR. Shown is stratification by the presence of the NPM1 mutation (A) and by the level of ELF4/MEF (B). These bars were median lines for each group. *, p < 0.009 against Wt-NPM1; **, p < 0.03 against MEF/ELF4-L, assessed by analysis of variance followed by Scheffe's multiple comparison test.