FIGURE 1.

Neuronatin level is increased in axillary skin biopsy samples collected from malin and laforin mutant LD patients. Skin biopsy samples obtained from three controls (sample numbers 1718, 1762, and 1848) and three LD patients (one laforin and two malin mutants) were stained immunohistochemically using neuronatin antibody. Each LD skin sample showed PAS-positive Lafora bodies. Hsc70/Hsp70 antibody was used as positive control that detects Lafora bodies. In negative control (NC), sample was processed without primary antibody. Scale bar, 20 μm.