Table 3.
Frequency distribution of the TopBP1 genotypes/alleles in cases and controls, and the risk of breast cancer
| Variables | Cases (n, %)/controls (n, %) | OR (95 % CI)a | p |
|---|---|---|---|
| rs116645643 | |||
| AA | 512 (95.9)/545 (98.0) | 1.00 (ref.) | |
| AG | 21 (3.9)/11 (2.0) | 2.19 (0.96–4.31) | >0.05 |
| GG | 1 (0.2)/0 (0.0) | – | |
| A | 1045 (97.8)/1101 (99.0) | 1.00 (ref.) | |
| G | 23 (2.1)/11 (0.1) | 2.22 (1.11–4.52) | 0.03 |
| p-trendb | 0.05 | ||
| AG or GG vs. AAc | 2.16 (1.02–4.47) | >0.05 | |
| AG or AA vs GGd | – | – | |
| rs115160714 | |||
| CC | 506 (94.7)/548 (98.6) | 1.00 (ref.) | |
| CT | 23 (4.4)/7 (1.2) | 3.54 (1.56–8.39) | 0.002 |
| TT | 5 (0.9)/1 (0.2) | 5.40 (0.63–46.64) | 0.004 |
| C | 1035 (96.9)/1103 (99.2) | 1.00 (ref.) | |
| T | 33 (3.1)/9 (0.8) | 3.97 (1.81–8.25) | 0.001 |
| p-trendb | 0.0006 | ||
| CT or TT vs. CCc | 3.81 (1.63–8.34) | 0.001 | |
| CT or CC vs. TTd | 5.23 (0.65–45.07) | 0.15 | |
| rs112843513 | |||
| CC | 391 (73.2)/389 (70.0) | 1.00 (ref.) | |
| C/delC | 143 (26.8)/167 (30.0) | 0.80 (0.67–1.06) | 0.28 |
| delC/delC | 0 (0.0)/0 (0.0) | – | |
| C | 925 (86.6)/945 (85.0) | 1.00 (ref.) | |
| delC | 143 (13.4)/167 (15.0) | 0.83 (0.62–1.14) | 0.22 |
| p-trendb | 0.24 | ||
| C/delC or delC/delC vs. CCc | 0.86 (0.65–1.11) | 0.23 | |
| C/delC or CC vs. delC/delCd | – | – |
del allele deletion
aAdjusted for age, family history, smoking status, alcohol intake, BMI, menarche, parity, menopausal status, and use of contraceptive and menopausal hormones
bTesting additive genetic model (Cochran–Armitage test for trend)
cTesting dominant genetic model
dTesting recessive genetic model