Fig. 5.

LRRK2 levels correlated with α-synuclein levels in PD brain. Quantitation (a) of LRRK2 Western blots (b) in the same brain regions in the PD cases (represented as an increase over control levels) and correlations with α-synuclein levels (c). The protein levels of LRRK2 were increased in the disease-affected areas (amygdala and cingulate) compared to the non-affected area (visual cortex) (a). Error bars = SEM. Multivariate analysis revealed a significant correlation between the increasing levels of α-synuclein and LRRK2 only in PD but not controls (c)