Table 1.

MicroRNAs and Their Target Genes in the Pathogenesis of CRC

miRNA	Up-regulated or down-regulated in CRC	Gene target	Reference
miR-16	Up-regulated	p53	117
miR-17	Up-regulated	PTEN, DLC1, ZBP1	91
miR-17-92 cluster	Up-regulated	E2F1a	108
miR-18a	Up-regulated	KRASa	168
miR-20a	Up-regulated	PTEN, RUNX1, TP53INP1	91
miR-21	Up-regulated	PTENa, PDCD4a,RECKa,TPM1a, SPRY2a, TIMP3a	90,113–115,169–171
miR-29a	Up-regulated	DNMT3a, DNMT3ba,MCL1a	91,172
miR-31	Up-regulated	BMP2	91
miR-32	Up-regulated	BTG2a	173,174
miR-92	Up-regulated	p63	91
miR-93	Up-regulated	AID	173
miR-96	Up-regulated	KRAS	87
miR-106a/b	Up-regulated	E2F1, p21	90
miR-122a	Up-regulated	MSH2, APCa	175
miR-135a/b	Up-regulated	MSH2, APCa	106
miR-155	Up-regulated	MLH1a,MSH2a,MSH6a	176
miR-181b	Up-regulated	CyclinD, VSNL1	113
miR-182	Up-regulated	IGFR1	91
miR-183	Up-regulated	EZRIN	91
miR-203	Up-regulated	SOX2, KLF4, BMI1	90,110
miR-223	Up-regulated	PTEN, RECK, ST5
miR-224	Up-regulated	SMAD4	109
miR-196b	Up-regulated	HOXB8	91
miR-451	Up-regulated	MIFa	178
miR-675	Up-regulated	pRB	111
let-7	Down-regulated	KRASa, cMYC	179
miR-9	Down-regulated	TCF4, MSH2	96,97
miR-34a/b/c	Down-regulated	CDK4a,CDK6a,E2F3a,CyclinE2a	97,180
miR-101	Down-regulated	COX2a	181
miR-126	Down-regulated	PIK3C2A, CRK, PGR
miR-129	Down-regulated	NOTCH1, CAMTA1	87
miR-137	Down-regulated	LSD1a, MITF, CDC42	87,101
miR-139	Down-regulated	β-CATENIN	183
miR-141	Down-regulated	TGFβ1, SIP1	184
miR-143	Down-regulated	DNMT3aa,KRASa,ERK5a,p53	88,89,117,118,122,123
miR-145	Down-regulated	IRS-1a, cMYC, YES1, STAT1, OCT4, SOX, KLF4, p53	88,89,116–121
miR-192	Down-regulated	DHFR, TS, TYMS	110,185,186
miR-195	Down-regulated	BCL2	187
miR-200a/b/c	Down-regulated	ZEB1a,ZEB2a	125,188
miR-215	Down-regulated	DHFR, TS, TYMS	186
miR-320	Down-regulated	PTENa	88,189
miR-342	Down-regulated	DNMT1	190
miR-491	Down-regulated	BClXL	191

^aA genetic target that has been validated for the specific miRNA.