Table 1. ANOVA table.

Source of variation	df	SS	MS	F	P-value
Modality	4	145.5	36.4	26.6	<0.0001
E1: reader* modality	36	49.3	1.4
AOI	10	160.7	16.1	10.9	<0.0001
E2: reader* ROI	90	133.2	1.5
Modality* ROI	40	222.6	5.6	12.4	<0.0001
E3: reader* modality* ROI	360	161.3	0.4

E1, the error variance term for testing modality differences; E2, the error variance term for testing ROI differences; E3, the error variance term for testing modality*ROI interaction; df, degrees of freedom; SS, sum of squares; MS, mean squared deviations