Table 2.
Frequency of adverse drug reactions (ADRs) to antituberculosis drugs by type and severity, CSEGSF/ENSP/FIOCRUZ-RJ, 2004-2008.
| Description of adverse reactions | N | (%) |
| Minor adverse reactions | 90 | 71.4 |
| Gastric irritation (nausea, vomiting), abdominal pain | 37 | 29.3 |
| Itchy skin | 20 | 15.9 |
| Arthralgia or arthritis | 13 | 10.3 |
| Headache | 6 | 4.8 |
| Sweat and urine orange | 6 | 4.8 |
| Behavior change (euphoria, insomnia, anxiety, and drowsiness) | 4 | 3.1 |
| Peripheral neuropathy (burning of the extremities) | 3 | 2.4 |
| Fever | 1 | 0.8 |
| Major adverse reactions | 8 | 6.4 |
| Exanthema | 3 | 2.4 |
| Hepatotoxicity (vomiting, hepatitis, changes in liver function tests) | 3 | 2.4 |
| Thrombocytopenia, leukopenia, eosinophilia, hemolytic anemia, agranulocytosis, vasculitis | 2 | 1.6 |
| Other§) | 28 | 22.2 |
| Total | 126 | 100.0 |
§
ADRs not described in the MoH Guia de Vigilância Epidemiológica: adenopathy, hallucinations, amenorrhea, anemia, increased uric acid, increased menstrual flow, painful urination, rash, weakness, jaundice, desquamative (scaly) lesions on the knees, urticarial lesions, malaise (sickness), other psychotic disorders, allergic reactions, and dizziness.