Table 3.
Adverse drug reactions (ADRs) to antituberculosis drugs by severity, drugs involved, and treatment period, CSEGSF/ENSP/FIOCRUZ-RJ, 2004-2008.
| Up to 2nd month N (%) | 3rd month onwards N (%) | Total ADRs N (%) | |
| Type of ADR # *) | |||
| Minor | 64 (71.1) | 26 (28.9) | 90 (91.8) |
| Major | 3 (37.5) | 5 (62.5) *) | 8 (8.2) |
| Drugs | |||
| R+H+Z | 50 (92.6) | 4 (0.8) | 54 (42.9) |
| R+H | 16 (42.1) | 22 (57.9) | 38 (30.2) |
| R | 7 (50.0) | 7 (50.0) | 14 (11.1) |
| H | 3 (33.3) | 6 (66.7) | 9 (7.1) |
| R+Z | 2 (100.0) | - | 2 (1.59) |
| Z | - | 1 (100.0) | 1 (0.8) |
| R+E | 1 (100.0) | - | 1 (0.8) |
| R+H+E | - | 1 (100.0) | 1 (0.8) |
| R+H+Z+E | - | 1 (100.0) | 1 (0.8) |
| Other combinations§) | 2 (40.0) | 3 (60.0) | 5 (4.0) |
| Total | 81 (64.3) | 45 (35.7) | 126 (100.0) |
p<0.05.
#Twenty-eight ADRs were excluded because they are not described in the MoH Guia de Vigilância Epidemiológica. Half of the ADRs occurred during the first two months of treatment.
R = rifampicin; H = isoniazid; Z = pyrazinamide; E = ethambutol.
Other combinations include: rifampicin + ethinylestradiol; rifampicin + isoniazid + paracetamol + sulfadiazine + sulfamethoxazole + omeprazole; rifampicin + efavirenz + metronidazole + sulfamethoxazole; rifampicin + isoniazid + efavirenz + sulfadiazine + sulfamethoxazole + pyrimethamine; isoniazid with alcohol intake.
D – dropout; C – cure; N – no ADR; S – ADR present; F – female; M – male; I1 – aged 0 to 19 years.; I2 – aged 20 to 49 years; I3 – aged 50 or older years; F1 – used up to four drugs; F2 – used five or more drugs; C1 – no comorbidity; C2 – one to three comorbidities; C3 – more than three comorbidities.