Table 4.

Univariate and Multivariate Analysis With Tumor Necrosis Factor α Responses Included in Models

	Length of Stay				CDSS
	Univariate Analysis (Unadjusted)		Multivariate Analysis (Adjusted)		Univariate Analysis (Unadjusted)		Multivariate Analysis (Adjusted)
Predictors	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Age (in mo)	1.02 (.92–1.15)	.650	1.01 (.89–1.16)	.815	1.08 (.96–1.22)	.175	1.12 (.96–1.31)	.154
Female sex	.86 (.32–2.31)	.760	.51 (.14–1.7)	.266	.97 (.32–2.95)	.959	.22 (.04–1.25)	.088
Presence of fever	1.71 (.57–5.15)	.342	1.62 (.46–5.72)	.455	NAa	NA	NA	NA
Duration of symptoms (<5 d)	1.11 (.42––2.95)	.833	.70 (.2–2.4)	.577	1.12 (.38–3.34)	.839	.46 (.09–2.47)	.366
TNF-α (<1000 pg/mL)	4.50 (1.27–15.95)	.020	5.82 (1.42–23.85)	.014	8.75 (2.47–30.95)	.001	20.27 (3.63–113.28)	.001
RSV loads (log10)	.82 (.52–1.31)	.424	.87 (.5–1.49)	.603	.89 (.53–1.49)	.650	.91 (.46–1.8)	.789

Length of stay >2 days and a CDSS >10 were selected as outcomes. Age and viral loads were analyzed as continuous variables, and presence of fever as a categorical variable. Bold type indicates the parameters that were significantly different in unadjusted and adjusted analysis.

Abbreviations: CDSS, clinical disease severity score; CI, confidence interval; NA, not applicable; OR, odds ratio; TNF-α, tumor necrosis factor α.

^a Fever was not included in the model for CDSS, because all subjects without fever had a CDSS <10.