Table 2.
TERT locus polymorphisms for which the meta-analysis demonstrated no nominally statistically significant association with cancer risk*
| Polymorphism data | Study characteristic | Meta-analysis findings | ||||||||||
| Polymorphism ID | Gene | Allele | Race or ethnicity† | No. of studies | Case subjects, No. | Control subjects, No. | Cancer type‡ | OR (95% CI) | P for Z test§ | I 2, % | P for Q test§ | Level of evidence║ |
| rs10073340 | CLPTM1L | T | White | 2 | 3851 | 3934 | Pancreas | 0.95 (0.73 to 1.23) | .68 | 89 | .002 | Weak |
| rs13167280 | TERT | T | White | 2 | 2989 | 3360 | Breast | 1.02 (0.91 to 1.16) | .69 | 0 | .82 | Weak |
| rs2075786 | TERT | T | White | 2 | 2953 | 3333 | Breast | 1.01 (0.94 to 1.09) | .77 | 0 | .45 | Weak |
| rs2075786 | TERT | T | Miscellany | 4 | 3134 | 3130 | Lung (miscellany) | 1.31 (0.98 to 1.75) | .06 | 74 | .01 | Weak |
| rs2075786 | TERT | T | Asian/Black | 3 | 2770 | 2750 | Lung (miscellany) | 1.45 (0.88 to 2.37) | .14 | 82 | .004 | Weak |
| rs2242652 | TERT | T | Miscellany | 2 | 4619 | 5360 | Lung (miscellany) | 1.06 (0.94 to 1.19) | .36 | 48 | .17 | Weak |
| rs2735940 | Intergenic | T | White | 2 | 1453 | 2584 | Bladder | 0.96 (0.87 to 1.05) | .37 | 0 | .77 | Weak |
| rs2735940 | Intergenic | T | White | 2 | 3180 | 3405 | Breast | 0.99 (0.93 to 1.07) | .92 | 0 | .99 | Weak |
| rs2735940 | Intergenic | T | Miscellany | 6 | 3682 | 4099 | Lung (miscellany) | 1.08 (0.95 to 1.23) | .25 | 59 | .032 | Weak |
| rs2735940 | Intergenic | T | White | 3 | 2746 | 3166 | Lung (miscellany) | 1.04 (0.89 to 1.22) | .62 | 65 | .06 | Weak |
| rs2735940 | Intergenic | T | Asian/Black | 3 | 936 | 933 | Lung (miscellany) | 1.20 (0.84 to 1.72) | .32 | 64 | .06 | Weak |
| rs2736098 | TERT | A | Miscellany | 2 | 1102 | 1182 | CNS | 1.07 (0.77 to 1.48) | .69 | 56 | .13 | Weak |
| rs2736098 | TERT | A | White | 2 | 8708 | 48804 | Prostate | 1.10 (1.00 to 1.20) | .05 | 83 | .015 | Weak |
| rs2736100 | TERT | C | Miscellany | 9 | 6002 | 50492 | Lung (SCLC) | 1.05 (0.99 to 1.10) | .06 | 13 | .33 | Strong |
| rs2736100 | TERT | C | Asian | 7 | 5019 | 19643 | Lung (squamous) | 1.08 (0.98 to 1.18) | .11 | 53 | .05 | Weak |
| rs2736100 | TERT | C | White | 2 | 3341 | 4533 | Melanoma (skin) | 1.03 (0.95 to 1.11) | .46 | 0 | .62 | Weak |
| rs2736109 | Intergenic | A | White | 2 | 2967 | 3331 | Breast | 0.96 (0.75 to 1.23) | .76 | 90 | .001 | Weak |
| rs2736122 | TERT | T | Miscellany | 3 | 11215 | 11908 | Lung (miscellany) | 0.97 (0.92 to 1.01) | .19 | 0 | .80 | Strong |
| rs2736122 | TERT | T | Miscellany | 2 | 3851 | 3934 | Pancreas | 1.00 (0.93 to 1.08) | .94 | 0 | .37 | Weak |
| rs2853669 | Intergenic | C | White | 3 | 3787 | 3824 | Breast | 1.02 (0.91 to 1.14) | .76 | 52 | .12 | Weak |
| rs2853676 | TERT | A | Miscellany | 2 | 3851 | 3934 | Pancreas | 0.93 (0.86 to 1.00) | .06 | 0 | .40 | Weak |
| rs2853676 | TERT | A | White | 2 | 3349 | 4542 | Melanoma (skin) | 1.16 (0.81 to 1.66) | .42 | 88 | .003 | Weak |
| rs2853677 | TERT | C | White | 2 | 2963 | 3340 | Breast | 1.03 (0.96 to 1.10) | .43 | 0 | .53 | Weak |
| rs2853677 | TERT | C | Miscellany | 4 | 2252 | 1809 | Lung (miscellany) | 1.31 (0.97 to 1.75) | .073 | 63 | .046 | Weak |
| rs2853677 | TERT | C | White | 2 | 2045 | 1615 | Lung (miscellany) | 1.34 (0.88 to 2.06) | .17 | 76 | .04 | Weak |
| rs2853677 | TERT | C | Asian/Black | 2 | 207 | 194 | Lung (miscellany) | 1.38 (0.62 to 3.05) | .43 | 74 | .05 | Weak |
| rs2853690 | TERT | T | White | 2 | 2983 | 3340 | Breast | 0.98 (0.89 to 1.08) | .74 | 0 | .60 | Weak |
| rs2853690 | TERT | T | Miscellany | 2 | 459 | 483 | Lung (NSCLC) | 0.89 (0.63 to 1.25) | .51 | 0 | .75 | Weak |
| rs31484 | CLPTM1L | T | Miscellany | 2 | 5302 | 6823 | Lung (miscellany) | 0.95 (0.61 to 1.48) | .83 | 97 | 2.1E-10 | Weak |
| rs401681 | CLPTM1L | T | White | 3 | 10254 | 36832 | Breast | 1.01 (0.97 to 1.05) | .65 | 0 | .47 | Strong |
| rs401681 | CLPTM1L | T | White | 4 | 5124 | 33326 | Colon | 1.05 (0.98 to 1.12) | .15 | 36 | .20 | Strong |
| rs401681 | CLPTM1L | T | White | 2 | 1095 | 30463 | Endometrium | 0.94 (0.73 to 1.21) | .61 | 86 | .007 | Weak |
| rs401681 | CLPTM1L | T | White | 2 | 1328 | 5861 | Testis | 1.18 (0.99 to 1.40) | .06 | 67 | .08 | Weak |
| rs401681 | CLPTM1L | T | Miscellany | 3 | 1573 | 37295 | Lung (SCLC) | 0.98 (0.90 to 1.07) | .66 | 9 | .33 | Weak |
| rs401681 | CLPTM1L | T | White | 3 | 4583 | 36338 | Lung (squamous) | 0.85 (0.70 to 1.04) | .11 | 86 | .001 | Weak |
| rs402710 | CLPTM1L | T | White | 2 | 3851 | 3934 | Pancreas | 1.14 (0.98 to 1.33) | .10 | 83 | .014 | Weak |
| rs466502 | CLPTM1L | G | Miscellany | 2 | 5302 | 6823 | Lung (miscellany) | 0.96 (0.65 to 1.42) | .84 | 97 | 8.2E-09 | Weak |
| rs4975605 | TERT | A | Miscellany | 3 | 11177 | 11835 | Lung (miscellany) | 0.96 (0.92 to 1.00) | .06 | 0 | .94 | Strong |
| rs4975605 | TERT | A | White | 2 | 3851 | 3934 | Pancreas | 1.03 (0.96 to 1.10) | .39 | 0 | .64 | Weak |
| rs7712562 | Intergenic | C | White | 2 | 2965 | 3341 | Breast | 1.00 (0.82 to 1.21) | .97 | 70 | .06 | Weak |
| rs7727912 | CLPTM1L | T | White | 2 | 4652 | 4981 | Lung (miscellany) | 1.01 (0.74 to 1.39) | .94 | 85 | .01 | Weak |
| MNS16a | TERT | S | Miscellany | 2 | 2058 | 2194 | Breast | 1.20 (0.84 to 1.71) | .32 | 85 | .01 | Weak |
| MNS16a | TERT | S | Miscellany | 2 | 990 | 1015 | Lung (NSCLC) | 0.99 (0.62 to 1.60) | .98 | 61 | .11 | Weak |
*
Telomerase reverse transcriptase (TERT) locus includes TERT and cleft lip and palate transmembrane 1-like (CLPTM1L) genes. ID = identification; CI = confidence interval; CNS = central nervous system; NSCLC = non–small cell lung cancer; OR =odds ratio; SCLC = small cell lung cancer.
†
Miscellany indicates a mix of different races.
‡
Lung (miscellany) indicates a mix of different histological subtypes.
§
All P values calculated by Z test or Q test were two-sided.
║
Levels of cumulative evidence (strong vs weak) were defined according to statistical power and between-study heterogeneity.