Table 1.
Alterations in plasma proteins in response to phenethyl isothiocyanate (PEITC) treatment in mouse mammary tumor virus (MMTV)-neu mice
| Protein name | Master No. | Protein ID | Ratio of protein abundance, PEITC vs control* | P† |
|---|---|---|---|---|
| α-Fetoprotein‡ | 168 | 1 | 1.55 | .07 |
| Transferrin (Mus musculus) | 275 | 2 | 1.49 | .05 |
| α-2-Macroglobulin‡ | 1159 | 19 | 1.47 | .05 |
| α-Fetoprotein‡ | 1045 | 20 | 1.97 | .03 |
| Chain L, crystal structure of the Fab fragment of mouse anti-human Fas antibody Hfe7a | 1335 | 21 | 1.65 | .05 |
| α-2-Macroglobulin‡ | 1248 | 22 | 2.01 | .01 |
| Chain L, Fab fragment of neutralizing monoclonal antibody 4c4 complexed with G-H loop from Fmdv‡ | 1333 | 23 | 2.63 | .06 |
| Apoa1 protein (Mus musculus) | 1380 | 24 | 1.88 | .05 |
| Anti-human seminoprotein monoclonal antibody (Mus musculus) | 1390 | 25 | 2.14 | .05 |
| Chain L, Fab fragment of neutralizing monoclonal antibody 4c4 complexed with G-H loop from Fmdv‡ | 1306 | 26 | 1.63 | .02 |
| α-Fetoprotein‡ | 1125 | 28 | –2.96 | .05 |
| Transthyretin (Mus musculus) | 1181 | 29 | 7.10 | .02 |
| Chain L, human immunodeficiency virus-1 capsid protein (P24) complex with Fab25.3 | 1382 | 34 | 1.53 | .01 |
| Immunoglobulin light chain variable region (Mus musculus) | 1354 | 36 | 2.05 | .01 |
| Predicted hypothetical protein (Mus musculus) | 1953 | 38 | –1.54 | .02 |
| Novel member of the major urinary protein gene family (Mus musculus) | 1742 | 40 | –3.52 | .04 |
| Albumin (Mus musculus) | 1711 | 41 | –1.49 | .04 |
* Plasma samples used were from MMTV-neu mice fed either control diet or 3 µmol PEITC/g diet (n = 3 mice per group). They were separated by two-dimensional electrophoresis and compared.
† All P values were calculated by two-sided Student’s t tests.
‡ The protein spots likely represent isoforms or posttranslational modification(s) of the same protein.