Table 2.
Annual mortality for years 1 to 10 after diagnosis of ovarian cancer*
| BRCA1 | BRCA2 | No mutation | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Year from diagnosis | Person-years | Deaths | Annual mortality† | Person-years | Deaths | Annual mortality | Person-years | Deaths | Annual mortality | Odds ratio (95% CI)‡ |
| <1 | 20.7 | 1 | 0.048 | 17.1 | 0 | 0 | 213 | 29 | 0.136 | 0.19 (0.03–1.47) |
| (1,2] | 61.8 | 9 | 0.145 | 41.9 | 4 | 0.095 | 563 | 110 | 0.195 | 0.64 (0.35–1.18) |
| (2,3] | 82.9 | 14 | 0.169 | 58.5 | 11 | 0.188 | 902 | 123 | 0.136 | 1.30 (0.81–2.06) |
| (3,4] | 88.7 | 20 | 0.225 | 64.3 | 6 | 0.093 | 992 | 133 | 0.134 | 1.27 (0.81–2.00) |
| (4,5] | 74.1 | 10 | 0.135 | 61.4 | 10 | 0.163 | 928 | 90 | 0.097 | 1.52 (0.90–2.55) |
| (5,6] | 64.7 | 7 | 0.108 | 51.0 | 11 | 0.216 | 854 | 42 | 0.049 | 3.16 (1.76–5.68) |
| (6,7] | 53.9 | 3 | 0.056 | 39.8 | 5 | 0.126 | 756 | 27 | 0.036 | 2.39 (1.06–5.41) |
| (7,8] | 45.1 | 3 | 0.066 | 29.0 | 6 | 0.207 | 621 | 35 | 0.056 | 2.16 (1.00–4.66) |
| (8,9] | 36.8 | 4 | 0.109 | 21.2 | 2 | 0.094 | 504 | 3 | 0.026 | 4.01 (1.47–10.9) |
| (9,10] | 28.2 | 5 | 0.177 | 17.3 | 0 | 0 | 444 | 9 | 0.020 | 5.41 (1.74–16.8) |
| All years | 596.4 | 77 | 0.129 | 426.6 | 56 | 0.131 | 7511.8 | 616 | 0.082 | |
* CI = confidence interval.† Annual mortality is the proportion of women alive at beginning of interval who died of ovarian cancer during the interval.
‡ Odds for dying of ovarian cancer in 1–year period for women alive at beginning of interval, carriers vs noncarriers; Breslow–Day heterogeneity of odds ratios P = .0001.