Table 2.
Genotype distribution by race/ethnicity
| GENOTYPE (n=317) | RACE/ETHNICITY
|
|||
|---|---|---|---|---|
| African N =148 (%) |
Indian N=82 (%) |
Mixed ethnicity N=67 (%) |
White N =20(%) |
|
|
| ||||
| GSTM11 | ||||
| Pos (n=221) | 115 (77.7) | 51 (62.2) | 43 (64.2) | 12 (60.0) |
| Null (n=96) | 33 (22.3) | 31 (37.8) | 24 (35.8) | 8 (40.0) |
| GSTP12 | ||||
| AA (n=105) | 29 (21.2) | 49 (62.8) | 20 (31.2) | 7 (41.2) |
| AG+GG (n=191) | 108 (78.8) | 29 (37.2) | 44 (68.8) | 10 (58.8) |
| NQO13 | ||||
| CC (n=191) | 104 (73.8) | 30 (40.0) | 43 (68.3) | 14 (77.8) |
| CT+TT (n=106) | 37 (26.2) | 45 (60.0) | 20 (31.8) | 4 (22.2) |
1
GSTM1 (positive or null genotype);
2
GSTP1; A allele codes for isoleucine, G allele codes for valine, AA is the wild type. Ile-Ile (AA), Ile-Val (AG)+Val-Val (GG).
3
NQO1; C allele codes for Proline, T allele codes for serine, CC is the wild type. Pro (CC), Pro/Ser (CT)+Ser (TT) For GSTP1 and NQO1, we were unable to assign a genotype to about 6% of DNA samples. Since these samples were different for each gene, poor DNA quality could not be a reason for non-amplification.