Table 3.
DNA damage (expressed as tail moment data) in the brain tissues of lean and obese Zucker rats that underwent sleep deprivation.
| Age | DNA damage (tail moment) | ||||
| Control | Sleep Deprivation | Positive control1 | |||
| Lean | Obese | Lean | Obese | ||
| 3 months | |||||
| 0.6 | 0.8 | 1.9 | 4.4 | 4.5 | |
| 1.2 | 1.2 | 1.2 | 3.7 | 6.2 | |
| 0.6 | 0.6 | 1.0 | 1.6 | 3.6 | |
| 0.5 | 0.1 | 1.5 | 2.4 | 7.2 | |
| 1.4 | 0.2 | 1.7 | 0.8 | 5.5 | |
| Mean±S.D. | 0.8±0.4 | 0.5±0.5 | 1.5±0.3 | 2.6±1.5 | 5.4±1.4# |
| 6 months | |||||
| 1.5 | 2.0 | 2.5 | 3.3 | 4.5 | |
| 1.3 | 1.4 | 2.0 | 2.7 | 6.2 | |
| 0.8 | 0.5 | 1.1 | 1.7 | 3.6 | |
| 0.4 | 0.3 | 2.4 | 1.3 | 7.2 | |
| 0.6 | 0.2 | 0.9 | 1.9 | 5.5 | |
| Mean±S.D. | 0.9±0.5 | 0.8±0.7 | 1.7±0.8 | 2.2±0.7 | 5.4±1.4# |
| 15 months | |||||
| 1.7 | 0.1 | 3.0 | 4.5 | 4.5 | |
| 0.9 | 0.2 | 2.7 | 2.8 | 6.2 | |
| 0.4 | 0.4 | 2.8 | 3.2 | 3.6 | |
| 0.8 | 0.3 | 2.7 | 3.8 | 7.2 | |
| 0.3 | 0.2 | 1.8 | 4.0 | 5.5 | |
| Mean±S.D. | 0.8±0.6 | 0.2±0.1 | 2.6±0.4 | 3.7±0.7*)¥ | 5.4±1.4# |
*
p<0.05 when compared to 3 and 6 months; ¥p<0.05 when compared to respective lean rats, #when compared to all groups. 110 μM H2O2 (hydrogen peroxide) for 10 min at 4°C.