Table 2. List of miRNAs altered by curcumin and H2O2.
| Control versus curcumin | Control versus H2O2 | Control versus H2O2+curcumin | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Downregulated |
Downregulated |
Downregulated |
||||||||||
| miRNA (miR) |
P value |
FR (FC) |
miRNA (miR) |
P value |
FR (FC) |
miRNA (miR) |
P value |
FR (FC) |
||||
| miR-302c |
0.033 |
−4.26 (0.24) |
miR-15a |
0.041 |
−13.98 (0.07) |
miR-7 |
0.011 |
−4.18 (0.24) |
||||
| miR-30e |
0.016 |
−7.37 (0.14) |
let-7a |
0.031 |
−5.91 (0.17) |
miR-30d |
0.014 |
−3.40 (0.29) |
||||
| miR-30d |
0.019 |
−4.19 (0.24) |
miR-126 |
0.045 |
−19.01 (0.05) |
miR-140–5p |
0.017 |
−10.42 (0.10) |
||||
| miR-30b |
0.02 |
−3.97 (0.30) |
miR-27a |
0.024 |
−22.15 (0.05) |
miR-141 |
0.031 |
−3.62 (0.28) |
||||
| miR-141 |
0.017 |
−4.46 (0.22) |
miR-29a |
0.036 |
−20.81 (0.05) |
miR-92a |
0.025 |
−3.60 (0.28) |
||||
| miR-92a |
0.006 |
−8.39 (0.12) |
miR-29b |
0.038 |
−20.86 (0.05) |
miR-26b |
0.018 |
−2.94 (0.34) |
||||
| miR-27b |
0.037 |
−2.78 (0.36) |
miR-22 |
0.024 |
−9.57 (0.10) |
miR-196b |
0.015 |
−6.84 (0.15) |
||||
| miR-30a |
0.007 |
−3.33 (0.30) |
Let-7d |
0.001 |
−7.09 (0.14) |
miR-30a |
0.006 |
−3.67 (0.27) |
||||
| miR-26b |
0.013 |
−4.26 (0.24) |
let-7i |
0.036 |
−9.51 (0.17) |
miR-30b |
0.029 |
−2.72 (0.37) |
||||
| miR-17 |
0.023 |
−4.06 (0.25) |
miR-106b |
0.04 |
−7.22 (0.14) |
miR-423–3p |
0.04 |
−6.15 (0.16) |
||||
| miR-15b |
0.037 |
−7.94 (0.13) |
let-7g |
0.005 |
−7.23 (0.14) |
let-7i |
0.027 |
−5.91 (0.17) |
||||
| miR-302a |
0.019 |
−4.06 (0.25) |
miR-28–5p |
0.011 |
−12.99 (0.08) |
miR-106b |
0.034 |
−9.15 (0.11) |
||||
| miR-30c |
0.014 |
−3.46 (0.29) |
miR-374a |
0.044 |
−9.93 (0.10) |
miR-17 |
0.04 |
−2.84 (0.35) |
||||
| miR-9 |
0.007 |
−4.13 (0.24) |
miR-100 |
0.007 |
−10.4 (0.10) |
miR-15b |
0.034 |
−10.18 (0.10) |
||||
| miR-196b |
0.032 |
−3.05 (0.33) |
miR-103 |
0.02 |
−6.27 (0.16) |
miR-302a |
0.017 |
−3.30 (0.30) |
||||
| miR-125a-5p |
0.003 |
−6.16 (0.16) |
miR-128 |
0.012 |
−15.4 (0.06) |
miR-29c |
0.021 |
−6.95 (0.14) |
||||
| miR-195 |
0.002 |
−4.26 (0.24) |
miR-150 |
0.031 |
−9.29 (0.11) |
miR-186 |
0.016 |
−4.51 (0.22) |
||||
| miR-423–3p |
0.027 |
−11.23(0.09) |
miR-7c |
0.024 |
−5.52 (0.18) |
miR-21 |
0.017 |
−3.45 (0.29) |
||||
| miR-21 |
0.017 |
−4.35 (0.23) |
Upregulated |
miR-302c |
0.047 |
−3.46 (0.29) |
||||||
| miR-28–3p |
0.041 |
−3.30 (0.30) |
miR-30d |
0.001 |
2.14 |
miR-9 |
0.016 |
−3.39 (0.30) |
||||
|
Upregulated |
miR-23a |
0.014 |
4.32 |
miR-30c |
0.012 |
−3.80 (0.26) |
||||||
| miR-18a |
0.042 |
2.35 |
miR-142–3p |
0.021 |
4.36 |
miR-320a |
0.034 |
−5.42 (0.18) |
||||
| miR-142–3p |
0.022 |
3.71 |
miR-143 |
0.037 |
10.83 |
miR-125a-5p |
0.003 |
−3.84 (0.26) |
||||
| miR-146a |
0.037 |
3.64 |
miR-124 |
0.017 |
14.23 |
miR-195 |
0.004 |
−4.06 (0.25) |
||||
| miR-20a |
0.002 |
3.4 |
miR-122 |
0.004 |
3.82 |
miR-28–3p |
0.036 |
−4.06 (0.25) |
||||
| miR-126 |
0.041 |
11.9 |
miR-125b |
0.032 |
5 |
miR-128 |
0.018 |
−6.17 (0.16) |
||||
| miR-29b |
0.001 |
5.79 |
miR-141 |
0.001 |
4.13 |
miR-27b |
0.009 |
−8.62 (0.12) |
||||
| miR-22 |
0.001 |
3.91 |
miR-9 |
0.001 |
4.28 |
miR-30e |
0.014 |
−17.16 (0.06) |
||||
| miR-150 |
0.022 |
5.7 |
miR-92a |
0.046 |
11.45 |
miR-143 |
0.021 |
−6.89 (0.15) |
||||
| miR-155 |
0.012 |
3.33 |
miR-27b |
0.014 |
14.06 |
Upregulated |
||||||
| miR-26b |
0.044 |
3.95 |
miR-22 |
0.012 |
20.1 |
|||||||
| miR-96 |
0.016 |
4.69 |
let-7b |
0.025 |
20.1 |
|||||||
| miR-21 |
0.04 |
2.49 |
miR-424 |
0.035 |
8.93 |
|||||||
| miR-23b |
0.009 |
9.34 |
miR-99a |
0.012 |
6.66 |
|||||||
| miR-17 |
0.014 |
4.33 |
let-7d |
0.038 |
16.63 |
|||||||
| miR-15b |
0.001 |
5.09 |
miR-150 |
0.005 |
4.59 |
|||||||
| miR-302a |
0.043 |
2.73 |
miR-20a |
0.001 |
2.89 |
|||||||
| miR-186 |
0.037 |
4.11 |
miR-23b |
0.011 |
5.89 |
|||||||
| miR-223 |
0.017 |
4.76 |
miR-29a |
0.012 |
4.12 |
|||||||
| miR-320a |
0.048 |
8.46 |
miR-29b |
0.016 |
4.02 |
|||||||
| miR-196b |
0.005 |
5.71 |
miR-155 |
0.049 |
2.4 |
|||||||
| miR-302b |
0.001 |
5.85 |
miR-146a |
0.037 |
2.89 |
|||||||
| miR-125a-5p |
0.007 |
4.23 |
miR-126 |
0.006 |
4.35 |
|||||||
| miR-195 |
0.004 |
3.28 |
miR-142–3p |
0.036 |
20.57 |
|||||||
| miR-28–3p |
0.001 |
4.04 |
||||||||||
| miR-302c |
0.026 |
13.19 |
||||||||||
| miR-423–3p |
0.001 |
5.71 |
||||||||||
| miR-30b |
0.001 |
3.52 |
||||||||||
| miR-30d | 0.024 | 2.12 | ||||||||||