Table 6. Change in the central subfield macular thickness from the baseline for each genotype.
| dbSNP ID | Gene | CSMT Change at month 3 | P value | CSMT Change at month 6 | P value |
|---|---|---|---|---|---|
|
rs1061170 |
CFH |
66.07(83)/54.76(17)/43.00(2) |
0.868 |
63.77(83)/56.35(17)/50.00(2) |
0.934 |
|
rs10490924 |
ARMS2 |
39.00(8)/57.65(37)/71.16(57) |
0.609 |
54.88(9) /63.59(37)/62.44(57) |
0.969 |
|
rs11200638 |
HTRA1 |
52.67(9)/53.54(37)/72.25(56) |
0.622 |
69.67(9)/58.32(37)/63.68(56) |
0.928 |
|
rs833069 |
VEGF-A |
25.66(38)/86.93(41)/85.30(23) |
0.008 |
28.71(38)/83.66(41)/79.57(23) |
0.011 |
| rs2071559 | KDR | 43.42(43)/76.23(47)/87.58(12) | 0.182 | 55.14(43)/64.51(47)/79.00(12) | 0.692 |
CFH=complement factor H; ARMS2=age related maculopathy susceptibility protein 2; HTRA1=high-temperature requirement A-1; CSMT=central subfield macular thickness; SNP=single nucleotide polymorphism; VEGF=vascular endothelial growth factor; KDR=kinase insert domain receptor. Data are mean logMAR vision change from baseline (n) for each genotype; major allele homozygous/heterozygous/risk allele homozygous.