Table 3. Distribution of IL-4 gene 70 bp VNTR polymorphism and allele frequencies between BD patients and controls.
| Genotype | Patients (n=238; %) | Controls (n=250; %) | χ2 | P value | OR (95%CI) |
|---|---|---|---|---|---|
| P1P1 |
8 (3.40) |
3 (1.2) |
17.33 |
p<0.001 |
|
| P1P2 |
62 (26.10) |
32 (12.8) |
|||
| P2P2 |
168 (70.50) |
215 (86) |
|||
| P1P1+ P1P2: P2P2 |
70:168 |
35:215 |
17.15 |
p<0.001 |
2.555 (1.629–4.052) |
| I P1P2+ P2P2: P1P1 |
230:8 |
247:3 |
2.585 |
p=0.107 |
0.349 (0.074–1.295) |
|
Allele frequency | |||||
| P1 |
78 (16) |
38 (7) |
17.98 |
p<0.001 |
2.381 (1.586–3.617) |
| P2 | 398 (84) | 462 (93) | |||
The results that are statistically significant are typed in bold. (Homozygous wild type (P1P1) heterozygous mutant type (P1P2) homozygous mutation type (P2P2), Wild type allele (P1) mutant type allele (P2).