Table 2.
Domain | Groupa | Latency (s) |
---|---|---|
MSI | NC100 – Vehicle | 6.1 ± 1.3 |
NC900 - Vehicle | 15.3 ± 2.3b | |
NC900 – 0.5 mg/kg DZ | 4.8 ± 0.7c | |
NC900 – 1 mg/kg DZ | 3.1 ± 0.4c | |
NC900 – 1.5 mg/kg DZ | 5.2 ± 0.9c | |
| ||
ISI | NC100 – Vehicle | 21.9 ± 4.7 |
NC900 - Vehicle | 123.8 ± 30.4d | |
NC900 – 0.5 mg/kg DZ | 208.1 ± 24.9e | |
NC900 – 1 mg/kg DZ | 191.4 ± 14.1e | |
NC900 – 1.5 mg/kg DZ | 238.6 ± 12.7e | |
| ||
SR | NC100 – Vehicle | 136.2 ± 26.1 |
NC900 - Vehicle | 32.6 ± 6.8f | |
NC900 – 0.5 mg/kg DZ | 40.5 ± 7.7 | |
NC900 – 1 mg/kg DZ | 59.9 ± 6.9g | |
NC900 – 1.5 mg/kg DZ | 110.6 ± 9.3g | |
| ||
LR | NC100 – Vehicle | 291.3 ± 8.7 |
NC900 - Vehicle | 59.4 ± 7.5h | |
NC900 – 0.5 mg/kg DZ | 131.4 ± 25.7i | |
NC900 – 1 mg/kg DZ | 246.9 ± 19.7i | |
NC900 – 1.5 mg/kg DZ | 269.2 ±12.4i | |
| ||
TP | NC100 – Vehicle | 296.7 ± 3.2 |
NC900 - Vehicle | 38.2 ± 7.9j | |
NC900 – 0.5 mg/kg DZ | 33.4 ± 3.8 | |
NC900 – 1 mg/kg DZ | 78.3 ± 10.7k | |
NC900 – 1.5 mg/kg DZ | 173.4 ± 24.1k | |
| ||
Attacks | NC100 – Vehicle | 300.0 ± 0.0 |
NC900 - Vehicle | 101.5 ± 11.6l | |
NC900 – 0.5 mg/kg DZ | 97.9 ± 16.5 | |
NC900 – 1 mg/kg DZ | 149.6 ± 35.2m | |
NC900 – 1.5 mg/kg DZ | 244.9 ± 17.3m |
N = 9-11 mice/line/dose.
T-test for vehicle-treated NC100 and NC900 mice [t1,18 = 3.258, p<0.004].
ANOVA for NC900 animals given DZ [F3,36 = 15.575, p<0.001]; vehicle versus 0.5 mg/kg (p<0.001); vehicle versus 1 mg/kg (p<0.001); vehicle versus 1.5 mg/kg (p<0.001).
T-test for NC100 and NC900 mice given vehicle [t1,18 = 2.988, p<0.008].
ANOVA for DZ-treated NC900 animals [F3,36 = 8.243, p<0.001]; vehicle versus 0.5 mg/kg (p<0.004); vehicle versus 1 mg/kg (p<0.003); vehicle versus 1.5 mg/kg (p<0.001).
T-test for NC100 and NC900 mice administered vehicle [t1,18 = 4.189, p<0.001].
ANOVA for NC900 animals given DZ [F3,36 = 20.471, p<0.001]; vehicle versus 1 mg/kg (p<0.006); vehicle versus 1.5 mg/kg (p<0.001).
T-test for vehicle-treated NC100 and NC900 mice [t1,18 = 20.279, p<0.001].
ANOVA for NC900 animals administered DZ [F3,36 = 31.462, p<0.001]; vehicle versus 0.5 mg/kg (p<0.035); vehicle versus 1 mg/kg (p<0.001); vehicle versus 1.5 mg/kg (p<0.001).
T-test for NC100 and NC900 mice given vehicle [t1,18 = 27.889, p<0.001].
ANOVA for DZ-treated NC900 animals [F3,36 = 10.920, p<0.001]; vehicle versus 1 mg/kg (p<0.030); vehicle versus 1.5 mg/kg (p<0.001).
T-test for NC100 and NC900 mice administered vehicle [t1,18 = 15.357, p<0.001].
ANOVA for NC900 animals given DZ [F3,36 = 11.931, p<0.001]; vehicle versus 1 mg/kg (p<0.033); vehicle versus 1.5 mg/kg (p<0.001).