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. Author manuscript; available in PMC: 2013 Mar 29.
Published in final edited form as: Behav Brain Res. 2009 Feb 21;201(1):179–191. doi: 10.1016/j.bbr.2009.02.010

Table 2.

Latencies to engage in social behaviors by NC100 and NC900 mice

Domain Groupa Latency (s)
MSI NC100 – Vehicle 6.1 ± 1.3
NC900 - Vehicle 15.3 ± 2.3b
NC900 – 0.5 mg/kg DZ 4.8 ± 0.7c
NC900 – 1 mg/kg DZ 3.1 ± 0.4c
NC900 – 1.5 mg/kg DZ 5.2 ± 0.9c
ISI NC100 – Vehicle 21.9 ± 4.7
NC900 - Vehicle 123.8 ± 30.4d
NC900 – 0.5 mg/kg DZ 208.1 ± 24.9e
NC900 – 1 mg/kg DZ 191.4 ± 14.1e
NC900 – 1.5 mg/kg DZ 238.6 ± 12.7e
SR NC100 – Vehicle 136.2 ± 26.1
NC900 - Vehicle 32.6 ± 6.8f
NC900 – 0.5 mg/kg DZ 40.5 ± 7.7
NC900 – 1 mg/kg DZ 59.9 ± 6.9g
NC900 – 1.5 mg/kg DZ 110.6 ± 9.3g
LR NC100 – Vehicle 291.3 ± 8.7
NC900 - Vehicle 59.4 ± 7.5h
NC900 – 0.5 mg/kg DZ 131.4 ± 25.7i
NC900 – 1 mg/kg DZ 246.9 ± 19.7i
NC900 – 1.5 mg/kg DZ 269.2 ±12.4i
TP NC100 – Vehicle 296.7 ± 3.2
NC900 - Vehicle 38.2 ± 7.9j
NC900 – 0.5 mg/kg DZ 33.4 ± 3.8
NC900 – 1 mg/kg DZ 78.3 ± 10.7k
NC900 – 1.5 mg/kg DZ 173.4 ± 24.1k
Attacks NC100 – Vehicle 300.0 ± 0.0
NC900 - Vehicle 101.5 ± 11.6l
NC900 – 0.5 mg/kg DZ 97.9 ± 16.5
NC900 – 1 mg/kg DZ 149.6 ± 35.2m
NC900 – 1.5 mg/kg DZ 244.9 ± 17.3m
a

N = 9-11 mice/line/dose.

b

T-test for vehicle-treated NC100 and NC900 mice [t1,18 = 3.258, p<0.004].

c

ANOVA for NC900 animals given DZ [F3,36 = 15.575, p<0.001]; vehicle versus 0.5 mg/kg (p<0.001); vehicle versus 1 mg/kg (p<0.001); vehicle versus 1.5 mg/kg (p<0.001).

d

T-test for NC100 and NC900 mice given vehicle [t1,18 = 2.988, p<0.008].

e

ANOVA for DZ-treated NC900 animals [F3,36 = 8.243, p<0.001]; vehicle versus 0.5 mg/kg (p<0.004); vehicle versus 1 mg/kg (p<0.003); vehicle versus 1.5 mg/kg (p<0.001).

f

T-test for NC100 and NC900 mice administered vehicle [t1,18 = 4.189, p<0.001].

g

ANOVA for NC900 animals given DZ [F3,36 = 20.471, p<0.001]; vehicle versus 1 mg/kg (p<0.006); vehicle versus 1.5 mg/kg (p<0.001).

h

T-test for vehicle-treated NC100 and NC900 mice [t1,18 = 20.279, p<0.001].

i

ANOVA for NC900 animals administered DZ [F3,36 = 31.462, p<0.001]; vehicle versus 0.5 mg/kg (p<0.035); vehicle versus 1 mg/kg (p<0.001); vehicle versus 1.5 mg/kg (p<0.001).

j

T-test for NC100 and NC900 mice given vehicle [t1,18 = 27.889, p<0.001].

k

ANOVA for DZ-treated NC900 animals [F3,36 = 10.920, p<0.001]; vehicle versus 1 mg/kg (p<0.030); vehicle versus 1.5 mg/kg (p<0.001).

l

T-test for NC100 and NC900 mice administered vehicle [t1,18 = 15.357, p<0.001].

m

ANOVA for NC900 animals given DZ [F3,36 = 11.931, p<0.001]; vehicle versus 1 mg/kg (p<0.033); vehicle versus 1.5 mg/kg (p<0.001).