Table 5. Association between EGFR exon polymorphisms and the risk of GC in the total population with gender differences.
| SNPs | Total population | Males | Females | ||||||
| Cases | Controls | OR (95% CI)b | Cases | Controls | OR (95% CI)c | Cases | Controls | OR (95% CI)c | |
| n = 387 | n = 392 | n = 271 | n = 237 | n = 116 | n = 155 | ||||
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||||
| rs2227983 | N = 371 | N = 386 | P a = 0.481 | N = 259 | N = 234 | P a = 0.402 | N = 112 | N = 152 | P a = 0.932 |
| AA | 109 (29.4) | 116 (30.1) | 1.00 | 85 (32.8) | 81 (33.7) | 1.00 | 24 (21.4) | 35 (23.0) | 1.00 |
| GA | 187 (50.4) | 205 (53.1) | 0.89 (0.39–2.08) | 116 (44.8) | 112 (46.2) | 3.47 (1.01–11.98) | 71 (63.4) | 93 (61.2) | 0.48 (0.07–3.44) |
| GG | 75 (20.2) | 65 (16.8) | 0.92 (0.50–1.70) | 58 (22.4) | 41 (20.1) | 1.66 (0.73–3.80) | 17 (15.2) | 24 (15.8) | 0.56 (0.11–2.84) |
| GA/GG | 262 (70.6) | 270 (69.9) | 0.93 (0.51–1.71) | 174 (67.2) | 153 (65.4) | 2.01 (0.92–4.42) | 88 (78.6) | 117 (77.0) | 0.55 (0.11–2.69) |
| Allele | P a = 0.428 | P a = 0.291 | P a = 0.911 | ||||||
| A | 405 (54.6) | 437 (56.6) | 1.00 | 286 (55.2) | 274 (58.6) | 1.00 | 119 (53.1) | 163 (53.6) | 1.00 |
| G | 337 (45.4) | 335 (43.4) | 1.09 (0.89–1.33) | 232 (44.8) | 194 (41.4) | 0.87 (0.68–1.12) | 105 (46.9) | 141 (46.4) | 0.98 (0.69–1.39) |
| rs2072454 | N = 384 | N = 390 | P a = 0.038 | N = 268 | N = 237 | P a = 0.050 | N = 116 | N = 153 | P a = 0.510 |
| CC | 130 (33.9) | 144 (36.9) | 1.00 | 97 (36.2) | 91 (38.4) | 1.00 | 33 (28.4) | 53 (34.6) | 1.00 |
| TC | 180 (46.9) | 197 (50.5) | 0.98 (0.61–1.57) | 114 (42.5) | 115 (48.5) | 0.98 (0.44–2.17) | 66 (56.9) | 82 (53.6) | 1.07 (0.34–3.36) |
| TT | 74 (19.3) | 49 (12.6) | 1.55 (0.80–3.00) | 57 (21.3) | 31 (13.1) | 5.12 (1.04–25.10) | 17 (14.7) | 18 (11.8) | 3.69 (0.39–34.79) |
| TC/TT | 254 (66.1) | 246 (63.1) | 1.02 (0.65–1.60) | 171 (63.8) | 146 (61.6) | 1.32 (0.61–2.87) | 83 (71.6) | 100 (65.4) | 0.78 (0.25–2.40) |
| Allele | P a = 0.050 | P a = 0.093 | P a = 0.288 | ||||||
| C | 440 (57.3) | 485 (62.2) | 1.00 | 308 (57.5) | 297 (62.7) | 1.00 | 132 (56.9) | 188 (61.4) | 1.00 |
| T | 328 (42.7) | 295 (37.8) | 1.23 (1.00–1.50) | 228 (42.5) | 177 (37.3) | 0.81 (0.63–1.04) | 100 (43.1) | 118 (38.6) | 0.83 (0.59–1.17) |
| rs17337023 | N = 382 | N = 390 | P a = 0.290 | N = 268 | N = 237 | P a = 0.441 | N = 114 | N = 153 | P a = 0.816 |
| AA | 123 (32.2) | 133 (34.1) | 1.00 | 92 (34.3) | 88 (37.1) | 1.00 | 31 (27.2) | 45 (29.4) | 1.00 |
| TA | 171 (44.8) | 185 (47.4) | 1.02 (0.59–1.76) | 109 (40.7) | 101 (42.6) | 1.25 (0.56–2.79) | 62 (54.4) | 84 (54.9) | 0.58 (0.16–2.07) |
| TT | 88 (23.0) | 72 (18.5) | 0.95 (0.44–2.06) | 67 (25.0) | 48(20.3) | 5.47 (1.44–20.76) | 21 (18.4) | 24 (15.7) | 1.46 (0.23–9.14) |
| TA/TT | 259 (67.8) | 257 (65.9) | 1.08 (0.63–1.84) | 176 (65.7) | 149 (62.9) | 1.86 (0.87–3.96) | 83 (72.8) | 108 (70.6) | 0.72 (0.21–2.46) |
| Allele | P a = 0.200 | P a = 0.227 | P a = 0.569 | ||||||
| A | 417 (54.6) | 451 (57.8) | 1.00 | 293 (54.7) | 277 (58.4) | 1.00 | 124 (54.4) | 174 (56.9) | 1.00 |
| T | 347 (45.4) | 329 (42.2) | 1.14 (0.93–1.40) | 243 (45.3) | 197 (41.6) | 0.86 (0.67–1.10) | 104 (45.6) | 132 (43.1) | 0.91 (0.64–1.28) |
| rs1050171 | N = 365 | N = 379 | P a = 0.211 | N = 254 | N = 230 | P a = 0.641 | N = 111 | N = 149 | P a = 0.057 |
| GG | 269 (73.7) | 257 (67.8) | 1.00 | 185 (72.8) | 163 (70.9) | 1.00 | 84 (75.7) | 94 (63.1) | 1.00 |
| GA | 84 (23.0) | 107 (28.2) | 1.02 (0.42–2.50) | 61 (24.0) | 56 (24.3) | 7.35 (0.91–59.51) | 23 (20.7) | 51 (34.2) | 0.00 (0.00–) |
| AA | 12 (3.3) | 15 (4.0) | 0.81 (0.54–1.21) | 8 (3.1) | 11 (4.8) | 2.31 (0.40–13.26) | 4 (3.6) | 4 (2.7) | 0.00 (0.00–) |
| GA/AA | 96 (26.3) | 122 (32.2) | 0.80 (0.55–1.14) | 246 (96.9) | 219 (95.2) | 2.73 (0.48–15.65) | 27 (24.3) | 55 (36.9) | 4.84E8 (0.00–) |
| Allele | P a = 0.088 | P a = 0.446 | P a = 0.082 | ||||||
| G | 622 (85.2) | 621 (81.9) | 1.00 | 431 (84.8) | 382 (83.0) | 1.00 | 191 (86.0) | 239 (80.2) | 1.00 |
| A | 108 (14.8) | 137 (18.1) | 0.79 (0.60–1.04) | 77 (15.2) | 78 (17.0) | 0.88 (0.62–1.23) | 31 (14.0) | 59 (19.8) | 1.52 (0.95–2.45) |
| rs1140475 | N = 383 | N = 389 | P a = 0.848 | N = 267 | N = 236 | P a = 0.676 | N = 116 | N = 153 | P a = 0.779 |
| CC | 351 (91.6) | 355 (91.3) | 1.00 | 246 (92.1) | 215 (91.1) | 1.00 | 105 (90.5) | 140 (91.5) | 1.00 |
| TC | 32 (8.4) | 34 (8.7) | 1.20 (0.64–2.24) | 21 (7.9) | 21 (8.9) | 3.00 (0.37–24.17) | 11 (9.5) | 13 (8.5) | 0.39 (0.09–1.77) |
| Allele | P a = 0.852 | P a = 0.683 | P a = 0.784 | ||||||
| C | 734 (95.8) | 744 (95.6) | 1.00 | 513 (96.1) | 451 (95.6) | 1.00 | 221 (95.3) | 293 (95.8) | 1.00 |
| T | 32 (4.2) | 34 (4.4) | 0.95 (0.58–1.56) | 21 (3.9) | 21 (4.4) | 1.14 (0.61–2.11) | 11 (4.7) | 13 (4.2) | 0.89 (0.39–2.03) |
| rs2293347 | N = 374 | N = 381 | P a = 0.855 | N = 261 | N = 232 | P a = 0.310 | N = 261 | N = 232 | P a = 0.474 |
| GG | 203 (54.3) | 204 (53.5) | 1.00 | 140 (53.6) | 27 (11.6) | 1.00 | 63 (55.8) | 82 (55.0) | 1.00 |
| GA | 140 (37.4) | 141 (37.0) | 1.11 (0.49–2.51) | 101 (38.7) | 83 (35.8) | 0.32 (0.10–1.02) | 39 (34.5) | 58 (38.9) | 4.31E8 (0.00–) |
| AA | 31 (8.3) | 36 (9.4) | 1.13 (0.72–1.76) | 20 (7.7) | 122 (52.6) | 0.80 (0.35–1.86) | 11 (9.7) | 9 (6.0) | 0.59 (0.17–2.00) |
| GA/AA | 171 (45.7) | 177 (46.5) | 1.06 (0.71–1.57) | 121 (46.4) | 205 (88.4) | 0.64 (0.30–1.39) | 50 (44.2) | 67 (45.0) | 0.83 (0.25–2.75) |
| Allele | P a = 0.680 | P a <0.001 | P a = 0.701 | ||||||
| G | 546 (73.0) | 549 (72.0) | 1.00 | 381 (73.0) | 137 (29.5) | 1.00 | 165 (73.0) | 222 (74.5) | 1.00 |
| A | 202 (27.0) | 213 (28.0) | 0.95 (0.76–1.20) | 141 (27.0) | 327 (70.5) | 6.45 (4.89–8.51) | 61 (27.0) | 76 (25.5) | 0.93 (0.63–1.37) |
a
Two-sided test;
b
ORs were adjusted for age, gender and lifestyle factors;
c
ORs were adjusted for age and lifestyle factors.