Table 6. Association between EGFR exon polymorphisms and the risk of GC in the age-matching population with gender differences.
| SNPs | Age-matching population | Males | Females | ||||||
| Cases | Controls | OR (95% CI)b | Cases | Controls | OR (95% CI)c | Cases | Controls | OR (95% CI)c | |
| n = 294 | n = 294 | n = 188 | n = 161 | ||||||
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||||
| rs2227983 | N = 284 | N = 288 | P a = 0.855 | N = 182 | N = 158 | P a = 0.613 | N = 102 | N = 130 | P a = 0.900 |
| AA | 72 (25.4) | 77 (26.7) | 1.00 | 50 (27.5) | 50 (31.6) | 1.00 | 22 (21.6) | 27 (20.8) | 1.00 |
| GA | 155 (54.6) | 158 (54.9) | 3.01 (0.92–9.82) | 90 (49.5) | 77 (48.7) | 11.91 (1.45–98.07) | 65 (63.7) | 81 (62.3) | 0.33 (0.05–2.35) |
| GG | 57 (20.1) | 53 (18.4) | 1.38 (0.68–2.83) | 42 (23.1) | 31 (19.6) | 1.98 (0.81–4.83) | 15 (14.7) | 22 (16.9) | 0.45 (0.09–2.27) |
| GA/GG | 212 (74.7) | 211 (73.3) | 1.60 (0.80–3.21) | 132 (72.5) | 108 (68.4) | 2.69 (1.13–6.38) | 80 (78.4) | 103 (79.2) | 0.43 (0.09–2.07) |
| Allele | P a = 0.605 | P a = 0.320 | P a = 0.747 | ||||||
| A | 299 (52.6) | 312 (54.2) | 1.00 | 190 (52.2) | 177 (56.0) | 1.00 | 109 (53.4) | 135 (51.9) | 1.00 |
| G | 269 (47.4) | 264 (45.8) | 0.94 (0.75–1.19) | 174 (47.8) | 139 (44.0) | 0.86 (0.63–1.16) | 95 (46.6) | 125 (48.1) | 1.06(0.74–1.53) |
| rs2072454 | N = 292 | N = 292 | P a = 0.036 | N = 186 | N = 161 | P a = 0.019 | N = 106 | N = 131 | P a = 0.798 |
| CC | 86 (29.5) | 100 (34.2) | 1.00 | 57 (30.6) | 59 (36.6) | 1.00 | 29 (27.4) | 41 (31.3) | 1.00 |
| TC | 145 (49.7) | 154 (52.7) | 1.27 (0.65–2.50) | 84 (45.2) | 82 (50.9) | 1.29 (0.54–3.06) | 61 (57.5) | 72 (55.0) | 1.07 (0.35–3.33) |
| TT | 61 (20.9) | 38 (13.0) | 13.48 (1.73–105.1) | 45 (24.2) | 20 (12.4) | 5.41E8 (0.00–) | 16 (15.1) | 18 (13.7) | 3.70 (0.40–34.60) |
| TC/TT | 206 (70.6) | 192 (65.7) | 1.72 (0.89–3.34) | 129 (69.5) | 102 (63.3) | 1.91 (0.82–4.45) | 77 (72.6) | 90 (68.7) | 1.29 (0.43–3.92) |
| Allele | P a = 0.029 | P a = 0.018 | P a = 0.562 | ||||||
| C | 317 (54.3) | 354 (60.6) | 1.00 | 198 (53.2) | 200 (62.1) | 1.00 | 119 (56.1) | 154 (58.8) | 1.00 |
| T | 267 (45.7) | 230 (39.4) | 0.77 (0.61–0.97) | 174 (46.8) | 122 (37.9) | 0.69 (0.51–0.94) | 93 (43.9) | 108 (41.2) | 0.90 (0.62–1.29) |
| rs17337023 | N = 291 | N = 292 | P a = 0.472 | N = 186 | N = 161 | P a = 0.530 | N = 105 | N = 131 | P a = 0.961 |
| AA | 86 (29.6) | 92 (31.5) | 1.00 | 59 (31.7) | 57 (35.4) | 1.00 | 27 (25.7) | 35 (26.7) | 1.00 |
| TA | 135 (46.4) | 142 (48.6) | 1.22 (0.62–2.41) | 76 (40.9) | 68 (42.2) | 1.59 (0.66–3.81) | 59 (56.2) | 74 (56.5) | 0.61 (0.17–2.15) |
| TT | 70 (24.1) | 58 (19.9) | 5.19 (1.442–18.66) | 51 (27.4) | 36 (22.4) | 14.03 (1.74–112.88) | 19 (18.1) | 22 (16.8) | 1.21 (0.20–7.57) |
| TA/TT | 205 (70.5) | 200 (68.5) | 1.65 (0.85–3.18) | 127 (68.3) | 104 (64.6) | 2.49 (1.08–5.74) | 78 (74.3) | 96 (73.2) | 0.70 (0.21–2.40) |
| Allele | P a = 0.292 | P a = 0.249 | P a = 0.803 | ||||||
| A | 307 (52.7) | 326 (55.8) | 1.00 | 194 (52.2) | 182 (56.5) | 1.00 | 113 (53.8) | 144 (55.0) | 1.00 |
| T | 275 (47.3) | 258 (44.3) | 0.88 (0.70–1.11) | 178 (47.8) | 140 (43.5) | 0.84 (0.62–1.13) | 97 (46.19) | 118 (45.0) | 0.96 (0.66–1.37) |
| rs1050171 | N = 278 | N = 283 | P a = 0.205 | N = 176 | N = 156 | P a = 0.060 | N = 102 | N = 127 | P a = 0.126 |
| GG | 207 (74.5) | 195 (68.9) | 1.00 | 130 (73.9) | 112 (71.8) | 1.00 | 77 (75.5) | 83 (65.4) | 1.00 |
| GA | 65 (23.4) | 76 (26.9) | 5.11 (0.61–42.65) | 44 (25.0) | 35 (22.4) | 6.71E10 (0.00−) | 21 (20.6) | 41 (32.3) | 0.00 (0.00−) |
| AA | 6 (2.2) | 12 (4.2) | 3.80 (0.51–28.40) | 2 (1.1) | 9 (5.8) | 9.11E9 (0.00−) | 4 (3.9) | 3 (2.4) | 0.00 (0.00−) |
| GA/AA | 71 (25.5) | 88 (31.1) | 0.89 (0.41–1.94) | 46 (26.1) | 44 (28.2) | 2.42 (0.67–8.72) | 25 (24.51) | 44 (34.6) | 0.50 (0.16–1.54) |
| Allele | P a = 0.079 | P a = 0.230 | P a = 0.220 | ||||||
| G | 479 (86.2) | 466 (82.3) | 1.00 | 304 (86.4) | 259 (83.0) | 1.00 | 175 (85.78) | 207 (81.5) | 1.00 |
| A | 77 (13.8) | 100 (17.7) | 1.34 (0.97–1.85) | 48 (13.6) | 53 (17.0) | 1.30 (0.85–1.98) | 29 (14.22) | 47 (18.5) | 1.37 (0.83–2.27) |
| rs1140475 | N = 291 | N = 291 | P a = 0.648 | N = 185 | N = 160 | P a = 0.427 | N = 106 | N = 131 | P a = 0.780 |
| CC | 269 (92.4) | 266 (91.4) | 1.00 | 173 (93.5) | 146 (91.2) | 1.00 | 96 (90.6) | 120 (91.6) | 1.00 |
| TC | 22 (7.6) | 25 (8.6) | 0.86 (0.27–2.76) | 12 (6.5) | 14 (8.8) | 2.22 (0.26–18.74) | 10 (9.4) | 11 (8.4) | 0.35 (0.08–1.65) |
| Allele | P a = 0.655 | P a = 0.436 | P a = 0.785 | ||||||
| C | 560 (96.2) | 557 (95.7) | 1.00 | 358 (96.8) | 306 (95.6) | 1.00 | 202 (95.28) | 251 (95.8) | 1.00 |
| T | 22 (3.8) | 25 (4.3) | 1.14 (0.64–2.05) | 12 (3.2) | 14 (4.4) | 1.37 (0.62–3.00) | 10 (4.72) | 11 (4.2) | 0.89 (0.37–2.13) |
| rs2293347 | N = 285 | N = 286 | P a = 0.706 | N = 181 | N = 159 | P a = 0.126 | N = 104 | N = 127 | P a = 0.481 |
| GG | 158 (55.4) | 160 (55.9) | 1.00 | 100 (55.2) | 88 (55.3) | 1.00 | 58 (55.8) | 72 (56.7) | 1.00 |
| GA | 105 (36.8) | 99 (34.6) | 0.46 (0.17–1.26) | 70 (38.7) | 52 (32.7) | 0.18 (0.05–0.64) | 35 (33.7) | 47 (37.0) | 6.29E8 (0.00−) |
| AA | 22 (7.7) | 27 (9.4) | 0.78 (0.38–1.60) | 11 (6.1) | 19 (11.9) | 0.86 (0.33–2.24) | 11 (10.6) | 8 (6.3) | 0.72 (0.23–2.34) |
| GA/AA | 127 (44.5) | 126 (44.0) | 0.69 (0.36–1.33) | 81 (44.8) | 71 (44.6) | 0.58 (0.24–1.37) | 46 (44.23) | 55 (43.3) | 1.07 (0.34–3.33) |
| Allele | P a = 0.816 | P a = 0.396 | P a = 0.526 | ||||||
| G | 421 (73.9) | 419 (73.3) | 1.00 | 270 (74.6) | 228 (71.7) | 1.00 | 151 (72.60) | 191 (75.2) | 1.00 |
| A | 149 (26.1) | 153 (26.7) | 1.03 (0.79–1.34) | 92 (25.4) | 90 (28.3) | 1.16 (0.83–1.63) | 57 (27.40) | 63 (24.8) | 0.87 (0.58–1.33) |
a
Two-sided test;
b
ORs were adjusted for age, gender and lifestyle factors;
c
ORs were adjusted for age and lifestyle factors.