Table 7. Association between the three possible impact SNPs and the risk of GC in the age-matching population with health lifestyle factors.
| SNPs | Eating on time | Average or not well salted food | Eating time >10 min | No smoking | No drinking | Daily eating breakfast | ||||||
| Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | |
| rs2072454 | N = 222 | N = 257 | N = 133 | N = 221 | N = 134 | N = 159 | N = 165 | N = 203 | N = 147 | N = 178 | N = 175 | N = 259 |
| CC | 69 (31.1) | 89 (34.6) | 35 (26.3) | 69 (31.2) | 38 (28.4) | 48 (30.2) | 52 (31.5) | 65 (32.0) | 43 (29.3) | 57 (32.0) | 53 (30.3) | 88 (34.0) |
| TC | 110 (49.5) | 135 (52.5) | 74 (55.6) | 123 (55.7) | 72 (53.7) | 91 (57.2) | 83 (50.3) | 111 (54.7) | 77 (52.4) | 97 (54.5) | 85 (48.6) | 139 (53.7) |
| TT | 43 (19.4) | 33 (12.8) | 24 (18.0) | 29 (13.1) | 24 (17.9) | 20 (12.6) | 30 (18.2) | 27 (13.3) | 27 (18.4) | 24 (13.5) | 37 (21.1) | 32 (12.4) |
| P a | 0.145 | 0.363 | 0.445 | 0.419 | 0.474 | 0.049 b | ||||||
| rs1050171 | N = 211 | N = 250 | N = 125 | N = 214 | N = 127 | N = 152 | N = 159 | N = 198 | N = 141 | N = 172 | N = 163 | N = 253 |
| GG | 157 (74.4) | 171 (68.4) | 93 (74.4) | 147 (68.7) | 93 (73.2) | 103 (67.8) | 120 (75.5) | 131 (66.2) | 114 (80.9) | 119 (69.2) | 119 (73.0) | 174 (68.8) |
| GA | 50 (23.7) | 69 (27.6) | 30 (24.0) | 60 (28.0) | 32 (25.2) | 42 (27.6) | 34 (21.4) | 60 (30.3) | 24 (17.0) | 47 (27.3) | 43 (26.4) | 69 (27.3) |
| AA | 4 (1.9) | 10 (4.0) | 2 (1.6) | 7 (3.3) | 2 (1.6) | 7 (4.6) | 5 (3.1) | 7 (3.5) | 3 (2.1) | 6 (3.5) | 1 (0.6) | 10 (4.0) |
| P a | 0.232 | 0.432 | 0.298 | 0.150 | 0.063 | 0.107 | ||||||
| rs2293347 | N = 218 | N = 252 | N = 131 | N = 217 | N = 130 | N = 156 | N = 163 | N = 199 | N = 142 | N = 174 | N = 172 | N = 254 |
| GG | 119 (54.6) | 141 (56.0) | 70 (53.4) | 124 (57.1) | 71 (54.6) | 90 (57.7) | 84 (51.5) | 112 (56.3) | 70 (49.3) | 99 (56.9) | 96 (55.8) | 143 (56.3) |
| GA | 81 (37.2) | 87 (34.5) | 55 (42.0) | 76 (35.0) | 48 (36.9) | 52 (33.3) | 64 (39.3) | 73 (36.7) | 58 (40.8) | 62 (35.6) | 61 (35.5) | 87 (34.3) |
| AA | 18 (8.3) | 24 (9.5) | 6 (4.6) | 17 (7.8) | 11 (8.5) | 14 (9.0) | 15 (9.2) | 14 (7.0) | 14 (9.9) | 13 (7.5) | 15 (8.7) | 24 (9.4) |
| P a | 0.788 | 0.278 | 0.818 | 0.590 | 0.382 | 0.948 | ||||||
a
two-sided test;
b
OR = 1.92, 95% CI = 1.07–3.44, P<0.05 by logistic regression analyses adjusted for age, gender and lifestyle factors.