Figure 1. Flow of Information in the modeling framework.

The figure shows the communication between the transport-phenomena and agent-based modules that is at the heart of the modeling platform. Information relevant to bioreactor hydrodynamics and mass transport is communicated from the transport-phenomena module to the agent-based module where cells, modeled as agents, detect the local concentrations (and other continuum variables) and act based on the rules attributed to them. The cellular information is then relayed back to the transport-phenomena module to complete the circuit.