Table 4. Rules.

Behavior	Rule
Proliferation	Cell proliferation occurs until confluence as per assigned probabilities (Table 2)
Migration	Migration occurs either via persistent random walk (under normoxic conditions) or chemotaxis (under hypoxic conditions)
	If local oxygen concentration >0.0672 mol/m3, cells display persistent random walk
	Cell speed during persistent random walk = 10 µm/hr
	If local oxygen concentration <0.0672 mol/m3, chemotaxis begins
	Chemotaxis speed = 20 µm/hr
Apoptosis	If a cell experiences hypoxia for more than 15 hours, it dies of hypoxia-induced apoptosis
	If, while performing chemotaxis, a cell ends up in a region rich in oxygen, it goes back to display persistent random walk

The table summarizes the rules used to simulate cellular dynamics.