Table 1.
Performance in open field (OF), elevated plus maze (EPM), partner preference (PP), social interaction (SI), and pacing tasks and associated levels of E2, P4, DHP, and 3α,5α-THP in serum, midbrain, hippocampus, diencephalon, and cortex
| Diestrus | Behavioral estrus |
F(1,15) | p | r | |
|---|---|---|---|---|---|
| A Exploration/anxiety/social behaviors | |||||
| Central entries | 22±3 | 46±5* | 12.88 | 0.002 | |
| Open arm time | 12±4 | 83±32* | 5.33 | 0.03 | |
| Proximity to male | 81±13 | 203±18* | 28.95 | 0.001 | |
| Proximity to female | 78±13 | 21±5* | 13.24 | 0.002 | |
| Social interaction | 47±7 | 103±11* | 17.64 | 0.001 | |
|
| |||||
| B Sexual behaviors | |||||
| LQ, % | 10±4 | 95±2* | 29.59 | 0.001 | |
| Lordosis ratings | 0.5±0.1 | 2.7±0.1* | 21.75 | 0.001 | |
| % of exits | 1±1 | 71±10* | 25.86 | 0.001 | |
| PQ, % | 0±0 | 88−5* | 267.00 | 0.0001 | |
| AQ, % | 5±2 | 34±5* | 40.76 | 0.00001 | |
|
| |||||
| C E2 | |||||
| Plasma, ng/ml | 2.8±0.7 | 21.8±2.0* | 8.02 | 0.01 | |
| Midbrain, ng/g | 1.4±0.1 | 2.2±0.3* | 7.72 | 0.01 | |
| Hippocampus, ng/g | 1.9±0.1 | 2.7±0.2* | 8.82 | 0.01 | |
| Diencephalon, ng/g | 1.5±0.1 | 2.1±0.1* | 4.59 | 0.04 | |
| Cortex, ng/g | 1.8±0.2 | 2.4±0.1* | 5.61 | 0.03 | |
| Interbrain, ng/g | 1.1±0.2 | 2.1±0.3* | 3.57 | 0.05 | |
|
| |||||
| D P4 | |||||
| Plasma, ng/ml | 1.7±0.2 | 18.8±1.7* | 14.78 | 0.001 | |
| Midbrain, ng/g | 1.4±0.1 | 2.1±0.2* | 4.55 | 0.04 | |
| Hippocampus, ng/g | 1.4±0.1 | 2.2±0.3* | 9.29 | 0.01 | |
| Diencephalon, ng/g | 0.9±0.1 | 1.5±0.1* | 9.64 | 0.01 | |
| Cortex, ng/g | 1.1±0.1 | 1.6±0.1* | 6.37 | 0.02 | |
| Interbrain, ng/g | 1.2±0.1 | 2.0±0.2* | 7.21 | 0.04 | |
|
| |||||
| E DHP | |||||
| Plasma, ng/ml | 5.9±1.8 | 23.2±3.9* | 4.32 | 0.05 | |
| Midbrain, ng/g | 5.0±1.0 | 17.3±0.4* | 9.95 | 0.006 | |
| Hippocampus, ng/g | 5.2±1.1 | 12.4±2.4* | 4.56 | 0.05 | |
| Diencephalon, ng/g | 1.9±0.2 | 4.6±0.6* | 4.53 | 0.05 | |
| Cortex, ng/g | 2.0±0.5 | 4.0±0.2* | 4.88 | 0.04 | |
| Interbrain, ng/g | 0.9±0.1 | 2.1±0.1* | 4.11 | 0.05 | |
|
| |||||
| F 3α,5α-THP | |||||
| Plasma, ng/ml | 4.2±0.2 | 14.8±3.1* | 5.73 | 0.04 | NA |
| Midbrain, ng/g | 2.5±0.3 | 5.0±0.6* | 7.71 | 0.01 | OF 0.51, PP 0.46, LQ 59, LR 55, % exits 0.48, PQ 0.65 |
| Hippocampus, ng/g | 3.6±0.3 | 5.4±0.6* | 5.79 | 0.03 | OF 0.46, EPM 69, PP 0.31, LQ 0.48 |
| Diencephalon, ng/g | 2.3±0.3 | 3.3±0.3* | 4.56 | 0.04 | OF 0.51, PP 0.51, SI 0.54, LR 0.47, % exits 0.53, PQ 0.51 |
| Cortex, ng/g | 2.3±0.3 | 3.2±0.2* | 4.86 | 0.04 | OF 0.64, PP 0.47 |
| Interbrain, ng/g | 1.9±0.1 | 2.8±0.2* | 3.99 | 0.04 | NA |
*
All correlations shown are significant at p ≤ 0.05.