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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Kidney Int. 2013 Jan 16;83(4):568–581. doi: 10.1038/ki.2012.441

Figure 1.

Figure 1

(A) Diagram of mitochondrial fusion-fission. Mitochondria are dynamic organelles that constantly undergo fusion and fission processes to maintain an interconnected network in healthy cells. Mitochondrial fusion is mediated by Mfn1, Mfn2, and OPA1, while fission mainly involves Drp1 and Fis1. (B, C) Mitochondrial morphology in human kidney tubular epithelial (HK-2) cells. A control HK2 cell shows filamentous mitochondria (B), whereas mitochondria become fragmented in high glucose treated cells (C). Red: mitochondria; Blue: Nuclei.