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. 2013 Jan 16;83(4):635–646. doi: 10.1038/ki.2012.447

Figure 8.

Figure 8

Adrenocorticotropic hormone (ACTH) gel protects from cecal ligation puncture (CLP)–induced septic acute kidney injury better than α-melanocyte-stimulating hormone (MSH). Mice were pretreated with ACTH gel (10 IU/kg) or an equal molar amount of α-MSH (71 μg/kg) or an equal volume of vehicle (normal saline) and subjected to CLP or sham surgery. Mice were followed up for 24 h and killed. (a) Kidney sections prepared for hematoxylin and eosin staining to evaluate histological injury; original magnification, × 400. (b) Blood was collected and serum creatinine levels were determined; *, #P<0.01 versus vehicle-treated CLP group (n=8); *P<0.05 versus α-MSH-treated CLP group (n=8). (c) Tubular injury score was estimated; *, #P<0.01 versus vehicle (Veh.)-treated CLP group (n=8); *P<0.05 versus α-MSH-treated CLP group (n=8). (d) Systolic blood pressure was measured at indicated time points; *, #P<0.01 versus vehicle (Veh.)-treated CLP group (n=8); *P<0.05 versus α-MSH-treated CLP group (n=8).