Regional distribution of molecules related with Aβ metabolism. After normalization within each individual, levels of apoE in TBS fraction (a) and in TBS-TX fraction (b), APP (c), APP-CTFβ (d), BACE1 (e), presenilin-1 (f), NEP (g), IDE (h), LRP1 (i), LDLR (j), synaptophysin (k), PSD95 (l), lactate (m), and GFAP (n) are plotted by different brain areas with the average line of each area. The p < 0.05 was considered significant; paired t test with Holm correction for multiple comparisons. PS1 presenilin-1, SYP synaptophysin