Table 3.

Regional associations between Aβ in each fraction and molecules related to Aβ metabolism

	Aβ40 TBS		Aβ40 TX		Aβ40 GuHCl		Aβ42 GuHCl
	r	p value	r	p value	r	p value	r	p value
ApoE TBS	−0.6364	0.0261	−0.8182	0.0011	−0.8741	0.0002	−0.6783	0.0153
ApoE TX	−0.6853	0.0139	−0.8252	0.001	−0.8112	0.0014	−0.7972	0.0019
APP	0.3427	0.2756	0.2308	0.4705	0.1049	0.7456	0.4056	0.1908
APP–CTFβ	0.2098	0.5128	0.035	0.9141	−0.035	0.9141	0.2378	0.4568
BACE1	−0.2517	0.4299	−0.1748	0.5868	−0.2028	0.5273	−0.007	0.9828
PS1	0.5524	0.0625	0.2587	0.4168	0.1608	0.6175	0.4056	0.1908
NEP	0.0839	0.7954	−0.2098	0.5128	−0.2867	0.3663	−0.1818	0.5717
IDE	0.8182	0.0011	0.7133	0.0092	0.7413	0.0058	0.6364	0.0261
LRP1	0.7343	0.0065	0.5245	0.08	0.4056	0.1908	0.6643	0.0185
LDLR	−0.3357	0.2861	−0.2937	0.3541	−0.1399	0.6646	−0.3077	0.3306
GFAP	−0.7483	0.0051	−0.6853	0.0139	−0.6573	0.0202	−0.5245	0.08
Lactate	−0.6364	0.0261	−0.6014	0.0386	−0.7133	0.0092	−0.6154	0.0332
SYP	0.5874	0.0446	0.5175	0.0849	0.5175	0.0849	0.4196	0.1745
PSD95	0.8951	<.0001	0.7902	0.0022	0.6993	0.0114	0.8112	0.0014

Correlation coefficient (r) and p value were acquired by the non-parametric Spearman rank test comparing median value of normalized levels of each protein from 21 individuals across 12 brain regions. Significant correlations are shown as bold text

PS1 presenilin-1, SYP synaptophysin