Table 4.

Regional associations among molecules related to Aβ metabolism

	ApoE TX	APP	APP-CTFβ	BACE1	PS1	NEP	IDE	LRP1	LDLR	GFAP	Lactate	SYP	PSD95
ApoE TBS	0.9021***	0.1888	0.3636	0.4406	−0.0839	0.1189	−0.6993*	−0.1329	0.1748	0.7762**	0.7622**	−0.4476	−0.5245
ApoE TX		−0.0909	0.1469	0.3706	−0.3077	0.021	−0.6154*	−0.3217	0.4056	0.6783*	0.7343**	−0.3706	−0.6853*
APP			0.8741***	0.3636	0.3636	0.1818	0.042	0.5944*	0	0.2378	0.1329	0.1888	0.5455
APP-CTFβ				0.5664	0.0559	−0.0909	−0.1469	0.4615	0.0839	0.4056	0.1538	0.1678	0.3916
BACE1					−0.4336	−0.5035	−0.6434*	−0.1888	0.0699	0.6014*	0.5594	0.007	−0.2797
PS1						0.5455	0.5315	0.7203**	−0.3916	−0.4196	−0.3007	−0.042	0.5455
NEP							0.2448	0.1818	−0.007	−0.0909	0.0769	0.1748	0.1189
IDE								0.6154*	0.014	−0.7762**	−0.7832**	0.4266	0.7413
LRP1									−0.2448	−0.3357	−0.3916	0.1818	0.8392***
LDLR										0.3497	0.0699	−0.1259	−0.3007
GFAP											0.6294*	−0.2937	−0.5455
Lactate												−0.2587	−0.6294**
SYP													0.4685

Values are Correlation coefficient (r). Significant correlations are shown as bold text

^*p < 0.05,

^**p < 0.01,

^***p < 0.001; non-parametric Spearman rank test comparing median value of normalized levels of each protein from 21 individuals across 12 brain regions