. Author manuscript; available in PMC: 2014 Apr 1.

Published in final edited form as: J Neural Transm (Vienna). 2012 Dec 21;120(4):571–576. doi: 10.1007/s00702-012-0956-y

Table 1.

Dopaminergic SPECT and PET and olfaction correlation studies in PD. It is possible that relative differences in olfactory and regional striatal dopaminergic correlations between SPECT and PET studies in part may reflect differences in spatial resolution between these imaging techniques or pharmacological differences between ligands.

Radioligand	Findings
[¹²³I]- -CIT DAT SPECT (Lehrner et al. 1995)	No significant correlation between striatal DAT binding and olfactory (threshold, memory, identification) functions.
[^99mTc] -TRODAT SPECT (Siderowf et al. 2005)	Higher UPSIT scores had strong correlation with striatal DAT binding that were higher in the putamen compared to the caudate nucleus.
[¹¹C]β-CFT DAT PET (Bohnen et al. 2007)	Higher UPSIT scores had better correlation with ventral compared to dorsal striatal DAT activity.
[¹¹C]β-CFT DAT PET (Bohnen et al. 2008)	UPSIT scores had best correlation with hippocampal compared to neostriatal DAT activity.
[¹²³I]-FP-CIT DAT SPECT (Deeb et al. 2010)	Moderate correlation between striatal DAT and UPSIT scores but no differences between affected versus less affected hemispheres. No correlation between striatal DAT and taste thresholds.
[¹²³I]-FP-CIT DAT SPECT (Berendse et al. 2011)	UPSIT scores had modest correlation with striatal (putaminal and caudate nucleus) DAT uptake, slightly better for the least denervated hemisphere.