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. Author manuscript; available in PMC: 2013 Mar 31.
Published in final edited form as: Growth Factors. 2009 Feb;27(1):40–49. doi: 10.1080/08977190802625179

Figure 5.

Figure 5

Effects of IL-1β with or without TSA on gene expression of MMP-13, MMP-1, MMP-3, and ADAMTS5 in human articular chondrocytes. Cells were cultured and treated with IL-1β and TSA for 24 hours as described in Figure 1. mRNA levels were quantified by real time RT-PCR and normalized to GAPDH. Chondrocytes from three patients were examined in separate experiments. Data were combined from these experiments after the group mean of the control without TSA is adjusted to 1. Data are presented as mean ± SEM. + (p<0.05) indicates significant IL-1β effects after comparison of the two group means with and without IL-1β in the absence of TSA; * (p<0.05) indicates significant TSA effects by comparing data with and without TSA at the same level of IL-1β.