Table 2.
Frequencies and percentages of DQB1 alleles in HCV patients and healthy controls and in responders and nonresponders to combined treatment of interferon and ribavirin.
| DQB1 |
HCV patients |
Healthy controls | PC | Responders | Nonresponders | PC |
|---|---|---|---|---|---|---|
| (n = 62) | (n = 57) | N = 41 | N = 21 | |||
| *02 | 32 (51.6%) | 41 (71.9%) | 0.175 | 24 (63.2%) | 6 (30%) | 0.026# |
| *0201 | 31 (50.0%) | 10 (17.5%) | 0.015† | 19 (50%) | 10 (50%) | 0.609 |
| *0202 | 30 (48.4%) | 10 (17.5%) | 0.027† | 18 (47.4%) | 10 (50%) | 1.000 |
| *0204 | 30 (48.4%) | 10 (17.5%) | 0.027† | 18 (47.4%) | 10 (50%) | 0.534 |
| *0205 | 9 (14.5%) | 35 (61.4%) | 0.000† | 7 (18.4%) | 1 (5%) | 0.241 |
| *03 | 40 (64.5%) | 53 (92.9%) | 0.017† | 27 (71.1%) | 11 (55%) | 0.255 |
| *0301 | 27 (43.5%) | 7 (12.3%) | 0.022† | 16 (42.1%) | 9 (45%) | 0.525 |
| *0303 | 2 (3.2%) | 35 (61.4%) | 0.000† | 1 (2.6%) | 1 (5%) | 0.575 |
| *0309 | 27 (43.5%) | 7 (12.3%) | 0.022† | 16 (42.1%) | 9 (45%) | 0.525 |
| *0312 | 2 (3.2%) | 35 (61.4%) | 0.000† | 1 (2.6%) | 1 (5%) | 0.575 |
| *0313 | 7 (11.3%) | 10 (17.5%) | 0.695 | 2 (5.3%) | 5 (25%) | 0.041# |
| *0315 | 2 (3.2%) | 35 (61.4%) | 0.000† | 1 (2.6%) | 1 (5%) | 0.575 |
| *0319 | 27 (43.5%) | 7 (12.3%) | 0.022† | 16 (42.1%) | 9 (45%) | 0.525 |
| *0320 | 2 (3.2%) | 35 (61.4%) | 0.000† | 1 (2.6%) | 1 (5%) | 0.575 |
| *0321 | 4 (6.6%) | 12 (21.1%) | 0.224 | 3 (7.9%) | 1 (5%) | 1.000 |
| *05 | 12 (19.4%) | 10 (17.5%) | 1.000 | 8 (21.1%) | 3 (15%) | 0.428 |
| *0501 | 32 (51.6%) | 41 (71.9%) | 0.175 | 6 (15.8%) | 2 (10%) | 0.701 |
| *0503 | 3 (4.8%) | 19 (33.3%) | 0.166 | 1 (2.6%) | 2 (10%) | 0.271 |
| *06 | 20 (32.3%) | 4 (7.0%) | 0.030† | 17 (44.7%) | 2 (10%) | 0.008# |
| *0601 | 5 (8.1%) | 9 (15.8%) | 0.823 | 3 (7.9%) | 2 (10%) | 0.568 |
| *0602 | 2 (3.2%) | 15 (26.3%) | 0.170 | 2 (5.3%) | 0 (0%) | 0.425 |
| *0603 | 10 (16.1%) | 22 (38.6%) | 0.171 | 8 (21.1%) | 2 (10%) | 0.468 |
| *0627 | 3 (4.8%) | 10 (17.5%) | 0.325 | 1 (2.6%) | 2 (10%) | 0.271 |
| *0628 | 10 (16.1%) | 7 (12.3%) | 0.886 | 8 (21.1%) | 2 (10%) | 0.250 |
| *0633 | 2 (3.2%) | 13 (22.8%) | 0.173 | 2 (5.3%) | 0 (0%) | 0.540 |
| *0634 | 2 (3.2%) | 17 (29.8%) | 0.085 | 1 (2.6%) | 1 (5%) | 0.575 |
# Significant difference at PC ≤ 0.05 (corrected P after the Bonferroni correction) between responder and non-responder patients to treatment, †Significant difference at PC ≤ 0.05 (corrected P after Bonferroni correction) between patients and healthy group. Each patient may have multiple suballeles or none at all, so that totals are not always equal to “n.”