Table 2.
Per-allele ORs for BER, HR, and MMR SNPs and lung cancer risk among non-Hispanic white smokers, stratified by MSH5 rs3131379 and CHRNA5 rs16969968 genotypes
| rs16969968 GG | rs16969968 AG/AA | rs3131379 GG | rs3131379 AG/AA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (258 ca, 624 co) | (483 ca, 852 co) | (548 ca, 1,166 co) | (196 ca, 307 co) | |||||||||
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| Pathway | Gene | SNP | OR | (95% CI) | OR | (95% CI) | pc | OR | (95% CI) | OR | (95% CI) | pc |
| MMRb | MLH1 | rs1800734 | 0.99 | (0.77, 1.28) | 0.85 | (0.70, 1.03) | 0.410 | 0.93 | (0.78, 1.11) | 0.84 | (0.61, 1.15) | 0.505 |
| MMR | MLH1 | rs1540354 | 0.99 | (0.76, 1.30) | 1.11 | (0.90, 1.37) | 0.605 | 0.95 | (0.78, 1.15) | 1.40 | (1.01, 1.95) | 0.039 |
| MMR | MLH1 | rs4579 | 1.01 | (0.82, 1.25) | 1.03 | (0.88, 1.21) | 0.905 | 1.07 | (0.92, 1.23) | 0.91 | (0.70, 1.19) | 0.344 |
| MMR | MSH2 | rs10188090 | 1.13 | (0.91, 1.41) | 1.00 | (0.85, 1.18) | 0.392 | 1.01 | (0.87, 1.17) | 1.22 | (0.93, 1.61) | 0.190 |
| MMR | MSH2 | rs2059520 | 1.12 | (0.89, 1.40) | 1.02 | (0.86, 1.21) | 0.561 | 1.00 | (0.85, 1.16) | 1.25 | (0.95, 1.65) | 0.141 |
| MMR | MSH2 | rs2303428 | 1.42 | (1.01, 2.01) | 1.13 | (0.87, 1.47) | 0.280 | 1.30 | (1.03, 1.64) | 1.05 | (0.67, 1.66) | 0.457 |
| MMR | MSH2 | rs12998837 | 1.01 | (0.75, 1.36) | 1.01 | (0.79, 1.28) | 0.992 | 0.88 | (0.71, 1.10) | 1.47 | (1.01, 2.13) | 0.025 |
| MMR | MSH2 | rs6544991 | 0.99 | (0.75, 1.30) | 0.95 | (0.77, 1.18) | 0.840 | 0.86 | (0.71, 1.04) | 1.41 | (1.00, 1.98) | 0.012 |
| MMR | MSH2 | rs13425206 | 1.00 | (0.59, 1.69) | 0.84 | (0.55, 1.28) | 0.642 | 0.89 | (0.62, 1.29) | 0.88 | (0.43, 1.81) | 0.973 |
| MMR | MSH2 | rs17036577 | 0.77 | (0.52, 1.15) | 1.08 | (0.81, 1.43) | 0.179 | 0.94 | (0.72, 1.22) | 0.98 | (0.62, 1.56) | 0.796 |
| MMR | MSH2 | rs1863332 | 1.08 | (0.74, 1.57) | 1.12 | (0.86, 1.47) | 0.865 | 1.09 | (0.86, 1.40) | 1.17 | (0.73, 1.88) | 0.816 |
| MMR | MSH2 | rs1981929 | 0.90 | (0.73, 1.11) | 0.98 | (0.84, 1.15) | 0.549 | 0.97 | (0.84, 1.12) | 0.91 | (0.70, 1.17) | 0.606 |
| MMR | MSH2 | rs4638843 | 0.98 | (0.72, 1.33) | 0.90 | (0.70, 1.15) | 0.595 | 1.07 | (0.86, 1.33) | 0.57 | (0.38, 0.86) | 0.009 |
| MMR | MSH2 | rs4952887 | 1.53 | (1.05, 2.22) | 0.88 | (0.66, 1.16) | 0.022 | 1.12 | (0.87, 1.44) | 1.00 | (0.62, 1.61) | 0.663 |
| MMR | MSH2 | rs6741393 | 1.20 | (0.66, 2.16) | 0.85 | (0.55, 1.32) | 0.342 | 1.12 | (0.76, 1.65) | 0.65 | (0.30, 1.44) | 0.260 |
| MMR | MSH2 | rs6753135 | 0.90 | (0.64, 1.26) | 1.01 | (0.79, 1.28) | 0.616 | 0.99 | (0.80, 1.24) | 0.90 | (0.60, 1.35) | 0.768 |
| MMR | MSH2 | rs10191478 | 1.16 | (0.93, 1.44) | 0.97 | (0.83, 1.14) | 0.197 | 1.01 | (0.87, 1.17) | 1.15 | (0.89, 1.50) | 0.354 |
| MMR | MSH2 | rs4987188 | 1.55 | (0.73, 3.27) | 1.09 | (0.61, 1.97) | 0.487 | 1.71 | (1.04, 2.83) | 0.38 | (0.11, 1.39) | 0.034 |
| MMR | MSH4 | rs5745325 | 1.26 | (1.01, 1.57) | 0.85 | (0.71, 1.02) | 0.009 | 0.90 | (0.77, 1.06) | 1.26 | (0.96, 1.66) | 0.035 |
| MMR | MSH4 | rs5745433 | 0.97 | (0.77, 1.23) | 1.05 | (0.88, 1.25) | 0.589 | 0.97 | (0.83, 1.14) | 1.20 | (0.91, 1.58) | 0.250 |
| MMR | MSH4 | rs3819949 | 0.86 | (0.69, 1.07) | 0.97 | (0.82, 1.15) | 0.407 | 0.97 | (0.83, 1.13) | 0.84 | (0.64, 1.10) | 0.359 |
| MMR | MSH4 | rs2047435 | 0.97 | (0.71, 1.31) | 1.13 | (0.90, 1.43) | 0.464 | 1.18 | (0.96, 1.45) | 0.74 | (0.50, 1.09) | 0.053 |
| MMR | MSH4 | rs1146644 | 0.85 | (0.69, 1.05) | 1.09 | (0.93, 1.28) | 0.072 | 1.11 | (0.96, 1.28) | 0.69 | (0.53, 0.89) | 0.002 |
| MMR | MSH4 | rs1498313 | 0.95 | (0.78, 1.17) | 1.11 | (0.94, 1.30) | 0.275 | 1.05 | (0.91, 1.22) | 1.03 | (0.80, 1.33) | 0.842 |
| MMR | MSH4 | rs5745513 | 1.64 | (1.16, 2.31) | 0.87 | (0.64, 1.19) | 0.008 | 1.06 | (0.81, 1.38) | 1.23 | (0.78, 1.94) | 0.526 |
| MMR | MSH4 | rs5745549 | 0.83 | (0.48, 1.44) | 1.60 | (1.02, 2.51) | 0.067 | 1.59 | (1.08, 2.34) | 0.45 | (0.21, 0.97) | 0.005 |
| MMR | MSH5 | rs6905572 | 1.01 | (0.74, 1.38) | 0.93 | (0.73, 1.19) | 0.785 | 1.01 | (0.82, 1.25) | 0.80 | (0.48, 1.34) | 0.385 |
| MMR | MSH5 | rs3131379 | 1.12 | (0.82, 1.52) | 1.55 | (1.22, 1.97) | 0.101 | NA | NA | |||
| MMR | MSH5 | rs707937 | 0.93 | (0.72, 1.21) | 1.07 | (0.88, 1.31) | 0.361 | 1.02 | (0.86, 1.22) | 1.30 | (0.84, 2.01) | 0.361 |
| MMR | MSH5 | rs707938 | 0.96 | (0.77, 1.19) | 1.28 | (1.09, 1.51) | 0.028 | 1.03 | (0.87, 1.21) | 1.16 | (0.79, 1.71) | 0.593 |
| MMR | MSH5 | rs707939 | 1.18 | (0.95, 1.47) | 0.78 | (0.65, 0.92) | 0.003 | 0.96 | (0.83, 1.12) | 0.98 | (0.67, 1.42) | 0.975 |
| MMR | MSH5 | rs2299851 | 0.90 | (0.63, 1.28) | 1.05 | (0.80, 1.37) | 0.418 | 1.05 | (0.83, 1.32) | 0.85 | (0.48, 1.49) | 0.485 |
| MMR | MSH5 | rs3117572 | 0.90 | (0.69, 1.19) | 1.06 | (0.86, 1.30) | 0.435 | 1.11 | (0.93, 1.32) | 0.68 | (0.40, 1.13) | 0.094 |
| MMR | MSH5 | rs3131382 | 0.82 | (0.53, 1.28) | 1.19 | (0.86, 1.65) | 0.217 | 1.15 | (0.88, 1.52) | 0.60 | (0.24, 1.49) | 0.186 |
| MMR | MSH5 | rs1802127 | 0.90 | (0.37, 2.19) | 1.18 | (0.68, 2.05) | 0.596 | 1.02 | (0.61, 1.71) | 1.99 | (0.58, 6.82) | 0.342 |
| MMR | MSH6 | rs1800932 | 0.93 | (0.71, 1.22) | 1.05 | (0.86, 1.29) | 0.550 | 1.08 | (0.90, 1.31) | 0.75 | (0.54, 1.04) | 0.068 |
| MMR | MSH6 | rs1800937 | 0.79 | (0.55, 1.15) | 1.03 | (0.80, 1.33) | 0.298 | 0.81 | (0.64, 1.04) | 1.53 | (1.01, 2.33) | 0.012 |
| MMR | MSH6 | rs1800935 | 0.88 | (0.70, 1.11) | 1.02 | (0.86, 1.22) | 0.370 | 0.98 | (0.83, 1.14) | 0.91 | (0.69, 1.21) | 0.751 |
| MMR | MSH6 | rs2710163 | 1.05 | (0.85, 1.29) | 1.03 | (0.87, 1.20) | 0.914 | 1.09 | (0.94, 1.26) | 0.81 | (0.62, 1.06) | 0.063 |
| MMR | MSH6 | rs2348244 | 1.07 | (0.80, 1.42) | 0.95 | (0.75, 1.19) | 0.562 | 1.05 | (0.85, 1.28) | 0.82 | (0.56, 1.21) | 0.271 |
| MMR | MSH6 | rs3136245 | 1.12 | (0.86, 1.44) | 0.94 | (0.76, 1.16) | 0.371 | 1.03 | (0.86, 1.23) | 0.93 | (0.66, 1.32) | 0.569 |
| MMR | MSH6 | rs330792 | 1.19 | (0.87, 1.63) | 1.09 | (0.85, 1.40) | 0.675 | 1.14 | (0.91, 1.43) | 1.08 | (0.72, 1.60) | 0.801 |
| MMR | MSH6 | rs1800936 | 0.85 | (0.62, 1.19) | 0.99 | (0.78, 1.25) | 0.585 | 0.84 | (0.67, 1.05) | 1.38 | (0.93, 2.04) | 0.032 |
| MMR | MSH6 | rs3136329 | 1.04 | (0.84, 1.30) | 1.01 | (0.86, 1.18) | 0.799 | 0.96 | (0.83, 1.11) | 1.24 | (0.96, 1.61) | 0.090 |
| BERb | APEX1 | rs1760945 | 0.83 | (0.55, 1.26) | 0.96 | (0.72, 1.29) | 0.521 | 0.97 | (0.74, 1.27) | 0.81 | (0.49, 1.33) | 0.576 |
| BER | APEX1 | rs1760944 | 0.96 | (0.78, 1.18) | 1.09 | (0.92, 1.28) | 0.307 | 1.05 | (0.91, 1.21) | 0.99 | (0.76, 1.30) | 0.622 |
| BER | APEX1 | rs3136817 | 1.05 | (0.84, 1.32) | 1.10 | (0.92, 1.32) | 0.729 | 1.01 | (0.86, 1.20) | 1.21 | (0.92, 1.61) | 0.288 |
| BER | APEX1 | rs1130409 | 1.21 | (0.99, 1.49) | 1.05 | (0.90, 1.23) | 0.327 | 1.06 | (0.92, 1.22) | 1.23 | (0.96, 1.58) | 0.376 |
| BER | LIG3 | rs3135962 | 0.78 | (0.51, 1.21) | 0.97 | (0.71, 1.33) | 0.348 | 1.01 | (0.76, 1.33) | 0.63 | (0.35, 1.14) | 0.147 |
| BER | LIG3 | rs3135989 | 1.72 | (1.11, 2.66) | 0.94 | (0.68, 1.30) | 0.029 | 1.18 | (0.88, 1.60) | 1.09 | (0.63, 1.87) | 0.807 |
| BER | LIG3 | rs2074516 | 0.86 | (0.61, 1.21) | 1.01 | (0.78, 1.31) | 0.586 | 0.97 | (0.77, 1.22) | 1.01 | (0.64, 1.58) | 0.883 |
| BER | LIG3 | rs4796030 | 0.88 | (0.71, 1.09) | 1.04 | (0.88, 1.22) | 0.202 | 0.99 | (0.86, 1.15) | 0.95 | (0.73, 1.24) | 0.785 |
| BER | LIG3 | rs1052536 | 1.18 | (0.96, 1.46) | 0.98 | (0.84, 1.16) | 0.190 | 1.03 | (0.89, 1.19) | 1.07 | (0.82, 1.38) | 0.812 |
| BER | MBD4 | rs3138360 | 0.87 | (0.56, 1.35) | 0.85 | (0.59, 1.22) | 0.907 | 0.84 | (0.61, 1.17) | 0.83 | (0.48, 1.44) | 0.985 |
| BER | MBD4 | rs140696 | 1.02 | (0.72, 1.45) | 1.09 | (0.82, 1.44) | 0.702 | 1.02 | (0.79, 1.31) | 1.14 | (0.73, 1.78) | 0.756 |
| BER | MBD4 | rs9821282 | 0.94 | (0.71, 1.25) | 0.95 | (0.76, 1.19) | 0.882 | 0.93 | (0.76, 1.14) | 0.95 | (0.67, 1.33) | 0.977 |
| BER | MPG | rs1013358 | 1.04 | (0.76, 1.42) | 0.76 | (0.61, 0.97) | 0.146 | 0.84 | (0.68, 1.03) | 0.95 | (0.63, 1.42) | 0.537 |
| BER | MPG | rs2562182 | 0.91 | (0.67, 1.25) | 0.80 | (0.64, 0.99) | 0.525 | 0.82 | (0.67, 1.01) | 0.92 | (0.61, 1.39) | 0.501 |
| BER | MPG | rs743725 | 0.95 | (0.71, 1.26) | 0.86 | (0.70, 1.05) | 0.628 | 0.88 | (0.73, 1.06) | 0.92 | (0.63, 1.32) | 0.758 |
| BER | MUTYH | rs3219489 | 0.90 | (0.70, 1.16) | 1.04 | (0.86, 1.25) | 0.419 | 0.90 | (0.76, 1.07) | 1.30 | (0.97, 1.74) | 0.028 |
| BER | MUTYH | rs3219487 | 1.22 | (0.86, 1.75) | 0.85 | (0.62, 1.16) | 0.153 | 0.93 | (0.71, 1.21) | 1.06 | (0.66, 1.69) | 0.628 |
| BER | MUTYH | rs3219484 | 0.80 | (0.52, 1.23) | 1.16 | (0.85, 1.58) | 0.159 | 1.10 | (0.83, 1.45) | 0.77 | (0.44, 1.34) | 0.277 |
| BER | MUTYH | rs3219474 | 0.86 | (0.58, 1.28) | 1.20 | (0.89, 1.62) | 0.182 | 1.09 | (0.82, 1.44) | 0.91 | (0.58, 1.43) | 0.487 |
| BER | NEIL1 | rs7182283 | 1.14 | (0.92, 1.40) | 0.98 | (0.83, 1.15) | 0.267 | 1.04 | (0.90, 1.21) | 1.01 | (0.78, 1.30) | 0.780 |
| BER | NEIL1 | rs4462560 | 0.88 | (0.70, 1.12) | 0.93 | (0.77, 1.13) | 0.705 | 0.86 | (0.72, 1.01) | 1.11 | (0.82, 1.51) | 0.137 |
| BER | NEIL2 | rs4841593 | 1.01 | (0.70, 1.46) | 1.16 | (0.86, 1.56) | 0.561 | 1.14 | (0.88, 1.48) | 0.91 | (0.56, 1.51) | 0.462 |
| BER | NEIL2 | rs904009 | 1.07 | (0.84, 1.37) | 0.98 | (0.82, 1.17) | 0.569 | 0.97 | (0.82, 1.14) | 1.20 | (0.90, 1.62) | 0.221 |
| BER | NEIL2 | rs2010628 | 1.09 | (0.85, 1.40) | 1.00 | (0.83, 1.20) | 0.572 | 1.01 | (0.86, 1.20) | 1.09 | (0.81, 1.47) | 0.718 |
| BER | NEIL2 | rs8191529 | 0.81 | (0.56, 1.18) | 0.92 | (0.68, 1.24) | 0.666 | 0.91 | (0.70, 1.18) | 0.75 | (0.44, 1.25) | 0.512 |
| BER | NEIL2 | rs804267 | 1.09 | (0.87, 1.36) | 1.03 | (0.87, 1.21) | 0.716 | 1.03 | (0.89, 1.20) | 1.11 | (0.84, 1.46) | 0.675 |
| BER | NEIL2 | rs8191534 | 1.05 | (0.82, 1.34) | 0.99 | (0.82, 1.18) | 0.699 | 0.97 | (0.82, 1.15) | 1.16 | (0.86, 1.55) | 0.333 |
| BER | NEIL2 | rs8191542 | 1.20 | (0.94, 1.55) | 0.98 | (0.80, 1.18) | 0.198 | 1.04 | (0.88, 1.24) | 1.13 | (0.83, 1.54) | 0.662 |
| BER | NEIL2 | rs8191589 | 1.15 | (0.90, 1.48) | 0.96 | (0.80, 1.17) | 0.292 | 1.02 | (0.85, 1.21) | 1.09 | (0.80, 1.48) | 0.724 |
| BER | NEIL2 | rs4840581 | 0.89 | (0.73, 1.09) | 1.02 | (0.87, 1.20) | 0.308 | 0.99 | (0.86, 1.15) | 0.87 | (0.68, 1.12) | 0.372 |
| BER | NEIL2 | rs4840583 | 1.07 | (0.86, 1.33) | 1.00 | (0.85, 1.17) | 0.593 | 1.00 | (0.86, 1.16) | 1.12 | (0.86, 1.46) | 0.436 |
| BER | NEIL2 | rs804256 | 0.98 | (0.80, 1.21) | 1.04 | (0.88, 1.23) | 0.781 | 1.03 | (0.89, 1.20) | 0.94 | (0.72, 1.22) | 0.584 |
| BER | NEIL2 | rs8191604 | 0.98 | (0.78, 1.25) | 1.00 | (0.84, 1.20) | 0.949 | 0.97 | (0.82, 1.14) | 1.11 | (0.84, 1.48) | 0.395 |
| BER | NEIL2 | rs4840585 | 0.99 | (0.68, 1.45) | 1.11 | (0.82, 1.49) | 0.640 | 1.12 | (0.86, 1.46) | 0.87 | (0.52, 1.44) | 0.417 |
| BER | NEIL2 | rs1874546 | 0.77 | (0.59, 0.99) | 0.94 | (0.78, 1.14) | 0.207 | 0.87 | (0.73, 1.04) | 0.85 | (0.63, 1.14) | 0.869 |
| BER | NEIL2 | rs8191649 | 1.03 | (0.80, 1.33) | 0.91 | (0.75, 1.10) | 0.447 | 0.93 | (0.78, 1.11) | 1.07 | (0.79, 1.44) | 0.448 |
| BER | NEIL2 | rs6982453 | 0.90 | (0.72, 1.11) | 0.92 | (0.79, 1.09) | 0.834 | 0.92 | (0.80, 1.07) | 0.89 | (0.69, 1.16) | 0.787 |
| BER | NEIL2 | rs1534862 | 1.02 | (0.79, 1.30) | 0.89 | (0.74, 1.08) | 0.432 | 0.92 | (0.78, 1.10) | 1.02 | (0.76, 1.37) | 0.562 |
| BER | NEIL2 | rs6997097 | 0.85 | (0.55, 1.30) | 0.94 | (0.68, 1.30) | 0.728 | 0.84 | (0.62, 1.13) | 1.18 | (0.71, 1.96) | 0.237 |
| BER | NEIL2 | rs1043180 | 0.94 | (0.69, 1.29) | 0.96 | (0.74, 1.23) | 0.984 | 0.94 | (0.75, 1.17) | 1.03 | (0.67, 1.58) | 0.688 |
| BER | NEIL2 | rs2645450 | 1.05 | (0.82, 1.33) | 1.16 | (0.96, 1.40) | 0.550 | 1.09 | (0.92, 1.29) | 1.14 | (0.84, 1.55) | 0.757 |
| BER | NEIL2 | rs904015 | 1.10 | (0.88, 1.36) | 0.92 | (0.78, 1.09) | 0.225 | 0.96 | (0.82, 1.12) | 1.08 | (0.83, 1.40) | 0.466 |
| BER | NTHL1 | rs12447809 | 0.95 | (0.72, 1.24) | 1.13 | (0.93, 1.37) | 0.336 | 1.00 | (0.83, 1.20) | 1.30 | (0.95, 1.79) | 0.145 |
| BER | NTHL1 | rs1132368 | 1.04 | (0.62, 1.75) | 0.73 | (0.48, 1.12) | 0.329 | 0.65 | (0.43, 0.96) | 1.90 | (1.01, 3.58) | 0.007 |
| BER | NTHL1 | rs2531213 | 0.83 | (0.47, 1.46) | 1.09 | (0.68, 1.77) | 0.466 | 1.02 | (0.68, 1.54) | 0.66 | (0.32, 1.39) | 0.316 |
| BER | NTHL1 | rs3211995 | 0.89 | (0.67, 1.20) | 0.97 | (0.79, 1.20) | 0.753 | 0.91 | (0.75, 1.11) | 1.03 | (0.73, 1.44) | 0.501 |
| BER | NTHL1 | rs2516740 | 1.01 | (0.78, 1.30) | 0.92 | (0.76, 1.11) | 0.465 | 0.88 | (0.74, 1.05) | 1.18 | (0.87, 1.60) | 0.097 |
| BER | NTHL1 | rs2516739 | 0.97 | (0.75, 1.25) | 0.92 | (0.76, 1.11) | 0.650 | 0.88 | (0.73, 1.05) | 1.17 | (0.86, 1.58) | 0.107 |
| BER | OGG1 | rs159153 | 1.01 | (0.80, 1.26) | 1.18 | (1.00, 1.40) | 0.256 | 1.07 | (0.92, 1.25) | 1.24 | (0.95, 1.62) | 0.332 |
| BER | OGG1 | rs1052133 | 1.02 | (0.80, 1.29) | 1.01 | (0.83, 1.22) | 0.997 | 1.01 | (0.85, 1.19) | 0.97 | (0.71, 1.32) | 0.804 |
| BER | OGG1 | rs293795 | 0.79 | (0.60, 1.05) | 1.11 | (0.90, 1.35) | 0.066 | 0.95 | (0.79, 1.15) | 1.08 | (0.76, 1.54) | 0.424 |
| BER | OGG1 | rs293794 | 0.81 | (0.61, 1.07) | 1.08 | (0.88, 1.32) | 0.114 | 0.95 | (0.79, 1.14) | 1.06 | (0.75, 1.50) | 0.484 |
| BER | OGG1 | rs293796 | 0.96 | (0.65, 1.41) | 1.26 | (0.95, 1.67) | 0.228 | 1.15 | (0.88, 1.49) | 1.13 | (0.71, 1.81) | 0.918 |
| BER | PCNA | rs3729558 | 0.93 | (0.76, 1.14) | 0.91 | (0.78, 1.07) | 0.977 | 0.94 | (0.81, 1.08) | 0.87 | (0.67, 1.13) | 0.607 |
| BER | PCNA | rs17349 | 1.07 | (0.78, 1.47) | 0.78 | (0.60, 1.02) | 0.165 | 0.81 | (0.64, 1.02) | 1.11 | (0.74, 1.69) | 0.204 |
| BER | PCNA | rs25406 | 1.07 | (0.87, 1.32) | 1.19 | (1.02, 1.40) | 0.522 | 1.16 | (1.01, 1.34) | 1.08 | (0.82, 1.40) | 0.636 |
| BER | PCNA | rs25405 | 1.07 | (0.77, 1.47) | 0.81 | (0.62, 1.05) | 0.212 | 0.83 | (0.66, 1.05) | 1.11 | (0.73, 1.68) | 0.263 |
| BER | PCNA | rs4239761 | 1.10 | (0.86, 1.41) | 1.03 | (0.85, 1.26) | 0.751 | 1.02 | (0.85, 1.22) | 1.10 | (0.81, 1.51) | 0.670 |
| BER | PNKP | rs7257463 | 1.02 | (0.82, 1.27) | 1.05 | (0.89, 1.24) | 0.821 | 1.08 | (0.93, 1.26) | 0.96 | (0.73, 1.26) | 0.472 |
| BER | PNKP | rs1290646 | 0.97 | (0.78, 1.21) | 0.96 | (0.82, 1.12) | 0.859 | 0.92 | (0.80, 1.07) | 1.09 | (0.84, 1.41) | 0.297 |
| BER | PNKP | rs3739177 | 1.40 | (0.97, 2.02) | 1.09 | (0.81, 1.45) | 0.309 | 1.24 | (0.96, 1.59) | 1.11 | (0.66, 1.87) | 0.775 |
| BER | PNKP | rs2257103 | 1.00 | (0.81, 1.24) | 1.07 | (0.91, 1.26) | 0.553 | 1.06 | (0.92, 1.23) | 0.99 | (0.76, 1.30) | 0.688 |
| BER | PNKP | rs2353005 | 0.76 | (0.57, 1.02) | 1.04 | (0.83, 1.30) | 0.106 | 0.98 | (0.81, 1.20) | 0.76 | (0.53, 1.10) | 0.221 |
| BER | POLB | rs3136711 | 0.99 | (0.67, 1.45) | 1.05 | (0.79, 1.39) | 0.853 | 1.02 | (0.79, 1.33) | 1.02 | (0.64, 1.63) | 0.952 |
| BER | POLB | rs2976244 | 1.14 | (0.76, 1.71) | 0.88 | (0.64, 1.21) | 0.324 | 0.95 | (0.71, 1.26) | 1.05 | (0.64, 1.73) | 0.706 |
| BER | POLB | rs3136790 | 1.11 | (0.79, 1.54) | 0.94 | (0.73, 1.22) | 0.468 | 0.96 | (0.76, 1.22) | 1.12 | (0.74, 1.67) | 0.562 |
| BER | POLB | rs3136797 | 1.79 | (0.93, 3.44) | 0.73 | (0.35, 1.49) | 0.076 | 0.88 | (0.48, 1.63) | 1.67 | (0.76, 3.67) | 0.211 |
| BER | POLB | rs2073664 | 1.14 | (0.75, 1.72) | 0.88 | (0.64, 1.22) | 0.330 | 0.94 | (0.70, 1.27) | 1.00 | (0.60, 1.66) | 0.834 |
| BER | POLI | rs3730668 | 0.89 | (0.72, 1.10) | 0.89 | (0.76, 1.05) | 0.892 | 0.94 | (0.81, 1.08) | 0.83 | (0.64, 1.08) | 0.423 |
| BER | POLI | rs476630 | 1.02 | (0.82, 1.27) | 1.15 | (0.97, 1.37) | 0.362 | 1.14 | (0.98, 1.34) | 0.94 | (0.70, 1.25) | 0.210 |
| BER | POLI | rs686881 | 1.14 | (0.74, 1.77) | 1.20 | (0.87, 1.65) | 0.888 | 1.17 | (0.87, 1.56) | 1.37 | (0.78, 2.42) | 0.581 |
| BER | POLI | rs3730814 | 0.99 | (0.78, 1.25) | 1.11 | (0.92, 1.34) | 0.389 | 1.12 | (0.95, 1.32) | 0.83 | (0.61, 1.15) | 0.093 |
| BER | POLI | rs3218786 | 1.62 | (0.85, 3.08) | 0.84 | (0.53, 1.33) | 0.087 | 1.07 | (0.71, 1.63) | 1.16 | (0.48, 2.81) | 0.924 |
| BER | POLI | rs8305 | 1.12 | (0.89, 1.41) | 1.00 | (0.84, 1.18) | 0.471 | 0.94 | (0.81, 1.11) | 1.26 | (0.96, 1.66) | 0.059 |
| BER | POLI | rs596986 | 1.14 | (0.74, 1.77) | 1.20 | (0.87, 1.65) | 0.888 | 1.17 | (0.87, 1.56) | 1.37 | (0.78, 2.42) | 0.581 |
| BER | PPP1R13L | rs6966 | 0.99 | (0.74, 1.33) | 0.91 | (0.74, 1.13) | 0.735 | 0.95 | (0.78, 1.16) | 0.94 | (0.67, 1.33) | 0.933 |
| BER | PPP1R13L | rs4803817 | 0.96 | (0.75, 1.22) | 0.94 | (0.78, 1.14) | 0.996 | 0.99 | (0.83, 1.17) | 0.80 | (0.58, 1.09) | 0.252 |
| BER | PPP1R13L | rs10412761 | 0.92 | (0.75, 1.14) | 0.91 | (0.78, 1.07) | 0.936 | 0.94 | (0.81, 1.09) | 0.87 | (0.67, 1.12) | 0.657 |
| BER | PPP1R13L | rs1005165 | 0.91 | (0.69, 1.20) | 0.91 | (0.73, 1.12) | 0.840 | 0.90 | (0.74, 1.10) | 1.01 | (0.71, 1.44) | 0.563 |
| BER | RAD18 | rs4389469 | 0.93 | (0.75, 1.15) | 0.99 | (0.84, 1.16) | 0.623 | 1.00 | (0.87, 1.16) | 0.87 | (0.67, 1.13) | 0.307 |
| BER | RAD18 | rs369032 | 0.93 | (0.75, 1.15) | 1.04 | (0.88, 1.22) | 0.414 | 1.00 | (0.87, 1.16) | 0.96 | (0.73, 1.25) | 0.724 |
| BER | RAD18 | rs2035221 | 1.02 | (0.70, 1.49) | 1.05 | (0.80, 1.38) | 0.922 | 1.23 | (0.95, 1.58) | 0.67 | (0.42, 1.08) | 0.029 |
| BER | RAD18 | rs593205 | 1.37 | (0.96, 1.97) | 1.15 | (0.87, 1.53) | 0.453 | 1.28 | (1.00, 1.66) | 1.06 | (0.67, 1.66) | 0.439 |
| BER | RAD18 | rs373572 | 1.01 | (0.80, 1.28) | 1.01 | (0.84, 1.21) | 0.970 | 1.04 | (0.88, 1.22) | 0.95 | (0.71, 1.26) | 0.533 |
| BER | RAD18 | rs13088787 | 0.94 | (0.69, 1.29) | 1.01 | (0.80, 1.29) | 0.666 | 1.09 | (0.88, 1.35) | 0.72 | (0.48, 1.09) | 0.072 |
| BER | RAD18 | rs615967 | 0.95 | (0.74, 1.21) | 1.02 | (0.84, 1.25) | 0.584 | 0.94 | (0.78, 1.12) | 1.13 | (0.83, 1.53) | 0.356 |
| BER | RAD18 | rs604092 | 0.99 | (0.76, 1.29) | 1.01 | (0.82, 1.24) | 0.927 | 0.95 | (0.79, 1.15) | 1.14 | (0.83, 1.57) | 0.383 |
| BER | SMUG1 | rs971 | 0.92 | (0.73, 1.14) | 1.10 | (0.94, 1.30) | 0.181 | 0.95 | (0.82, 1.11) | 1.28 | (0.98, 1.67) | 0.064 |
| BER | SMUG1 | rs3087404 | 0.92 | (0.75, 1.13) | 0.99 | (0.85, 1.16) | 0.601 | 0.92 | (0.80, 1.06) | 1.10 | (0.85, 1.43) | 0.200 |
| BER | TDG | rs172814 | 1.05 | (0.79, 1.41) | 0.77 | (0.61, 0.97) | 0.107 | 0.88 | (0.72, 1.08) | 0.81 | (0.56, 1.18) | 0.711 |
| BER | TDG | rs4135054 | 1.03 | (0.74, 1.44) | 1.17 | (0.92, 1.50) | 0.578 | 1.13 | (0.90, 1.42) | 1.05 | (0.70, 1.57) | 0.817 |
| BER | TDG | rs4135061 | 0.98 | (0.77, 1.25) | 0.90 | (0.75, 1.07) | 0.518 | 0.90 | (0.76, 1.06) | 1.04 | (0.77, 1.41) | 0.409 |
| BER | TDG | rs4135064 | 0.95 | (0.66, 1.37) | 1.25 | (0.95, 1.64) | 0.264 | 1.14 | (0.89, 1.47) | 1.08 | (0.70, 1.66) | 0.848 |
| BER | TDG | rs4135081 | 1.10 | (0.89, 1.37) | 1.03 | (0.87, 1.21) | 0.620 | 1.04 | (0.89, 1.21) | 1.12 | (0.85, 1.47) | 0.651 |
| BER | TDG | rs3751206 | 1.06 | (0.68, 1.66) | 1.03 | (0.76, 1.39) | 0.891 | 1.10 | (0.83, 1.46) | 0.91 | (0.52, 1.57) | 0.483 |
| BER | TDG | rs4135087 | 0.83 | (0.59, 1.19) | 0.92 | (0.70, 1.22) | 0.598 | 0.85 | (0.66, 1.10) | 0.86 | (0.57, 1.29) | 0.968 |
| BER | TDG | rs167715 | 0.91 | (0.64, 1.27) | 1.13 | (0.89, 1.44) | 0.348 | 0.97 | (0.77, 1.21) | 1.43 | (0.95, 2.16) | 0.096 |
| BER | TDG | rs10861152 | 0.95 | (0.77, 1.18) | 0.89 | (0.75, 1.05) | 0.637 | 0.88 | (0.75, 1.02) | 0.99 | (0.76, 1.30) | 0.408 |
| BER | TDG | rs1866074 | 1.09 | (0.89, 1.33) | 0.88 | (0.75, 1.03) | 0.115 | 0.96 | (0.84, 1.11) | 0.95 | (0.73, 1.24) | 0.940 |
| BER | TDG | rs4135106 | 0.88 | (0.57, 1.37) | 0.87 | (0.63, 1.19) | 0.912 | 0.87 | (0.65, 1.17) | 0.94 | (0.54, 1.61) | 0.789 |
| BER | TDG | rs4135128 | 0.96 | (0.65, 1.42) | 1.03 | (0.79, 1.36) | 0.796 | 1.09 | (0.85, 1.39) | 0.86 | (0.52, 1.42) | 0.360 |
| BER | UNG | rs3890995 | 0.95 | (0.72, 1.27) | 1.12 | (0.91, 1.39) | 0.375 | 1.03 | (0.85, 1.25) | 1.16 | (0.82, 1.65) | 0.601 |
| BER | UNG | rs1018783 | 1.05 | (0.80, 1.39) | 1.16 | (0.95, 1.43) | 0.576 | 1.03 | (0.85, 1.25) | 1.45 | (1.04, 2.03) | 0.085 |
| BER | UNG | rs2569987 | 1.01 | (0.77, 1.34) | 1.00 | (0.81, 1.23) | 0.848 | 1.08 | (0.89, 1.30) | 0.82 | (0.58, 1.16) | 0.175 |
| BER | UNG | rs246079 | 1.06 | (0.85, 1.31) | 1.21 | (1.03, 1.43) | 0.326 | 1.07 | (0.92, 1.24) | 1.48 | (1.13, 1.94) | 0.038 |
| BER | UNG | rs34259 | 1.13 | (0.87, 1.45) | 1.07 | (0.88, 1.29) | 0.723 | 1.02 | (0.86, 1.22) | 1.34 | (0.98, 1.83) | 0.128 |
| BER | XRCC1 | rs25487 | 0.91 | (0.73, 1.13) | 1.05 | (0.90, 1.24) | 0.309 | 0.98 | (0.84, 1.14) | 1.09 | (0.83, 1.42) | 0.566 |
| BER | XRCC1 | rs25486 | 0.90 | (0.73, 1.13) | 1.04 | (0.88, 1.23) | 0.343 | 0.97 | (0.84, 1.13) | 1.08 | (0.83, 1.41) | 0.548 |
| BER | XRCC1 | rs25489 | 1.06 | (0.64, 1.74) | 0.87 | (0.58, 1.31) | 0.604 | 0.87 | (0.61, 1.24) | 1.28 | (0.64, 2.58) | 0.323 |
| BER | XRCC1 | rs1799782 | 1.07 | (0.68, 1.68) | 1.05 | (0.74, 1.49) | 0.997 | 1.05 | (0.77, 1.42) | 1.17 | (0.60, 2.27) | 0.784 |
| BER | XRCC1 | rs3213344 | 1.09 | (0.69, 1.71) | 1.00 | (0.70, 1.42) | 0.799 | 1.02 | (0.75, 1.39) | 1.17 | (0.60, 2.27) | 0.732 |
| BER | XRCC1 | rs3213334 | 1.09 | (0.86, 1.38) | 0.95 | (0.79, 1.14) | 0.400 | 0.98 | (0.83, 1.16) | 0.99 | (0.74, 1.32) | 0.990 |
| BER | XRCC1 | rs2023614 | 0.87 | (0.59, 1.30) | 0.96 | (0.70, 1.31) | 0.705 | 0.86 | (0.65, 1.14) | 1.18 | (0.71, 1.97) | 0.269 |
| BER | XRCC1 | rs2854510 | 1.01 | (0.78, 1.31) | 0.93 | (0.76, 1.12) | 0.574 | 1.01 | (0.84, 1.20) | 0.82 | (0.60, 1.12) | 0.299 |
| BER | XRCC1 | rs2854509 | 1.17 | (0.92, 1.50) | 0.96 | (0.79, 1.15) | 0.203 | 1.02 | (0.86, 1.21) | 1.01 | (0.75, 1.35) | 0.952 |
| BER | XRCC1 | rs3213266 | 0.88 | (0.60, 1.30) | 0.94 | (0.70, 1.27) | 0.792 | 0.85 | (0.65, 1.12) | 1.20 | (0.73, 1.96) | 0.226 |
| BER | XRCC1 | rs3213255 | 1.12 | (0.91, 1.39) | 0.91 | (0.78, 1.07) | 0.124 | 1.01 | (0.87, 1.17) | 0.88 | (0.68, 1.14) | 0.387 |
| HRb | XRCC2 | rs3218536 | 0.90 | (0.60, 1.36) | 1.18 | (0.87, 1.60) | 0.227 | 1.08 | (0.82, 1.42) | 0.95 | (0.57, 1.58) | 0.644 |
| HR | XRCC2 | rs6964582 | 1.43 | (0.90, 2.30) | 1.18 | (0.81, 1.70) | 0.502 | 1.18 | (0.84, 1.66) | 1.57 | (0.89, 2.78) | 0.400 |
| HR | XRCC2 | rs3218438 | 1.43 | (1.03, 1.98) | 0.94 | (0.72, 1.23) | 0.047 | 0.97 | (0.76, 1.24) | 1.62 | (1.04, 2.52) | 0.032 |
| HR | XRCC2 | rs3218408 | 1.00 | (0.78, 1.30) | 1.11 | (0.93, 1.34) | 0.495 | 1.18 | (0.99, 1.40) | 0.83 | (0.61, 1.13) | 0.049 |
| HR | XRCC2 | rs3218373 | 1.08 | (0.76, 1.54) | 1.02 | (0.77, 1.35) | 0.785 | 1.08 | (0.84, 1.39) | 0.89 | (0.57, 1.42) | 0.466 |
| HR | XRCC2 | rs2040639 | 0.93 | (0.75, 1.15) | 0.97 | (0.82, 1.13) | 0.854 | 0.93 | (0.80, 1.08) | 1.09 | (0.84, 1.41) | 0.340 |
| HR | XRCC3 | rs861539 | 0.90 | (0.72, 1.11) | 0.88 | (0.75, 1.04) | 0.936 | 0.89 | (0.77, 1.04) | 0.87 | (0.67, 1.14) | 0.852 |
| HR | XRCC3 | rs3212102 | 0.93 | (0.47, 1.86) | 0.85 | (0.50, 1.46) | 0.872 | 0.73 | (0.44, 1.23) | 1.20 | (0.56, 2.54) | 0.278 |
| HR | XRCC3 | rs3212090 | 1.08 | (0.86, 1.34) | 1.17 | (0.98, 1.39) | 0.646 | 1.20 | (1.03, 1.40) | 0.95 | (0.72, 1.26) | 0.133 |
| HR | XRCC3 | rs3212079 | 1.18 | (0.81, 1.74) | 0.80 | (0.58, 1.10) | 0.107 | 0.91 | (0.68, 1.22) | 0.94 | (0.59, 1.49) | 0.881 |
| HR | XRCC3 | rs861530 | 1.05 | (0.83, 1.33) | 0.98 | (0.82, 1.18) | 0.717 | 0.93 | (0.79, 1.10) | 1.25 | (0.93, 1.67) | 0.070 |
| HR | XRCC3 | rs1799794 | 0.99 | (0.75, 1.29) | 1.13 | (0.92, 1.39) | 0.372 | 1.02 | (0.84, 1.22) | 1.27 | (0.91, 1.77) | 0.226 |
| HR | XRCC3 | rs861528 | 0.88 | (0.69, 1.12) | 0.90 | (0.75, 1.08) | 0.900 | 0.91 | (0.77, 1.07) | 0.88 | (0.66, 1.17) | 0.878 |
aAmong all cases and controls; AA, homozygous major allele; Aa, heterozygous; aa, homozygous minor allele; numbers do not sum to total due to missing.
b
MMR, mismatch repair; BER, base excision repair; HR, homologous recombination.
c
p-value for interaction.